Zapraszamy na wykład Roberta Zarnowskiego, PhD (University of Wisconsin-Madison, USA), który odbędzie się w dniu 24.02.2026. o godz. 13.00 w auli 1.05 Wydziału Biotechnologii Uniwersytetu Wrocławskiego (ul. F. Joliot-Curie 14a), wizytującego Uniwersytet Wrocławski w ramach programu zapraszania „profesorów wizytujących” (IDUB):
„The untold story of eDNA in Candida biofilm extracellular vesicles„.
Organizatorem jest dr Anna Jaromin, Zakład Lipidów i Liposomów, Wydział Biotechnologii Uniwersytetu Wrocławskiego.
Tematyka wykładu:
The fungal pathogen Candida albicans forms highly structured biofilms that resist antifungal drugs and evade host immune responses, resulting in persistent and difficult-to-treat infections. Exosome-like extracellular vesicles produced by C. albicans biofilms carry a complex cargo of proteins, carbohydrates, lipids, and nucleic acids. Both exosomal proteins and carbohydrates are key matrix components that strongly shape biofilm biology and fungal–host interactions. In contrast, the role of extracellular DNA (eDNA) remains largely mysterious. What types of eDNA are present in biofilms? Could it serve as a scaffold for the matrix? Does it influence biofilm organization? Is it genetically functional? Can eDNA contribute to antifungal resistance? Can exosomal cargo modulate interactions with the host immune system? And finally, what do we actually know about C. albicans biofilm exosomes produced during infection? Can they be isolated directly from infection sites?
Each question opens a window of opportunity into the as-yet-unknown strategies that allow C. albicans biofilms to survive and thrive. To find answers to these intriguing questions and uncover the secrets of exosomes in fungal biofilm resilience, please join the lecture by Dr. Robert Zarnowski (University of Wisconsin–Madison).
