Zainteresowania

• biochemistry molecular biology
• melanoma
• migration
• invasiveness
• foretinib
• met
• egfr
• tumor microenvironment
• general science technology
• lapatinib

Dyscyplina naukowa

• nauki medyczne

Najnowsze publikacje

• PARP1 as a marker of an aggressive clinical phenotype in cutaneous melanoma - a clinical and an in vitro study.
• The impact of cellular elements of TME on melanoma biology and its sensitivity to EGFR and MET targeted therapy
• Characterization of Melanoma Cell Lines Resistant to Vemurafenib and Evaluation of Their Responsiveness to EGFR- and MET-Inhibitor Treatment
• Melanoma stimulates the proteolytic activity of HaCaT keratinocytes
• The Influence of Tumor Microenvironment on Immune Escape of Melanoma
• Hypoxia and Extracellular Acidification as Drivers of Melanoma Progression and Drug Resistance
• Melanoma cells with diverse invasive potential differentially induce the activation of normal human fibroblasts
• Stromal Cells Present in the Melanoma Niche Affect Tumor Invasiveness and Its Resistance to Therapy
• Melanoma cells induce dedifferentiation and metabolic changes in adipocytes present in the tumor niche
• Combination of selected MET and EGFR inhibitors decreases melanoma cells’ invasive abilities.
• Expression level of EGFR and MET receptors regulates invasiveness of melanoma cells.
• The two faces of platinum hydrospirophosphorane complexes. Not only relevant catalysts but cytotoxic compounds as well.
• Combinations of EGFR and MET inhibitors reduce proliferation and invasiveness of mucosal melanoma cells
• Alpha-Enolase (ENO1) correlates with invasiveness of cutaneous melanoma - an in vitro and a clinical study.
• A fluorescent gelatin degradation assay to study melanoma breakdown of extracellular matrix.
• Gefitinib or lapatinib with foretinib synergistically induce a cytotoxic effect in melanoma cell lines.
• The sorafenib anti-relapse effect after alloHSCT is associated with heightened alloreactivity and accumulation of CD8+PD-1+ (CD279+) lymphocytes in marrow.
• Involvement of β- and γ-actin isoforms in actin cytoskeleton organization and migration abilities of bleb-forming human colon cancer cells.
• An end-to-end software solution for the analysis of high-throughput single-cell migration data.
• Novel hybrid composites based on double-decker silsesquioxanes functionalized by methacrylate derivatives and polyvinyl alcohol as potential materials utilized in biomedical applications