Zainteresowania

• biochemistry molecular biology
• chemical physics
• fhfs
• fgf12
• fgfs
• fgf11
• secretion
• immunology
• biotechnology
• nolc1

Dyscyplina naukowa

• biotechnologia

Najnowsze publikacje

• FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner.
• Low stability of integrin-binding deficient mutant of FGF1 restricts its biological activity.
• Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions.
• FGF homologous factors are secreted from cells to induce FGFR‐mediated anti‐apoptotic response
• FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex
• The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells.
• FGF1 protects FGFR1-overexpressing cancer cells against drugs targeting tubulin polymerization by activating AKT via two independent mechanisms
• Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity.
• The autoinhibitory function of D1 domain of FGFR1 goes beyond the inhibition of ligand binding.
• High affinity promotes internalization of engineered antibodies targeting FGFR1.