Zainteresowania

• biochemistry molecular biology
• golgi
• glycosylation
• n glycans
• golgi apparatus
• general science technology
• slc35a2
• nucleotide sugar transporters
• n glycan
• o glycan

Dyscyplina naukowa

• nauki medyczne
• nauki biologiczne

Najnowsze publikacje

• SLC35A5 protein - a Golgi complex member with putative nucleotide sugar transport activity.
• SLC35A2 deficiency reduces protein levels of core 1 β-1,3-galactosyltransferase 1 (C1GalT1) and its chaperone Cosmc and affects their subcellular localization
• Novel Insights into Selected Disease-Causing Mutations within the SLC35A1 Gene Encoding the CMP-Sialic Acid Transporter
• The glycosylation defect in solute carrier SLC35A2/SLC35A3 double knockout cells is rescued by SLC35A2–SLC35A3 and SLC35A3–SLC35A2 hybrids
• Missing the sweet spot: one of the two N-glycans on human Gb3/CD77 synthase is expendable.
• The solute carrier MFSD1 decreases the activation status of β1 integrin and thus tumor metastasis.
• Modified secreted alkaline phosphatase as an improved reporter protein for N-glycosylation analysis.
• Biosynthesis of GlcNAc-rich N- and O-glycans in the Golgi apparatus does not require the nucleotide sugar transporter SLC35A3
• Identification of novel potential interaction partners of UDP-galactose (SLC35A2), UDP-N-acetylglucosamine (SLC35A3) and an orphan (SLC35A4) nucleotide sugar transporters
• Mutations in the SLC35C1 gene, contributing to significant differences in fucosylation patterns, may underlie the diverse phenotypic manifestations observed in leukocyte adhesion deficiency type II patients
• Incorporation of fucose into glycans independent of the GDP-fucose transporter SLC35C1 preferentially utilizes salvaged over de novo GDP-fucose
• N-glycosylation of the human β1,4-galactosyltransferase 4 is crucial for its activity and Golgi localization
• Lysine at position 329 within a C-terminal dilysine motif is crucial for the ER localization of human SLC35B4.
• An insight into the orphan nucleotide sugar transporter SLC35A4.