{"id":36067,"date":"2022-06-20T15:06:00","date_gmt":"2022-06-20T13:06:00","guid":{"rendered":"https:\/\/biotech.uwr.edu.pl\/pracownia-biologii-medycznej\/"},"modified":"2026-06-25T13:02:26","modified_gmt":"2026-06-25T11:02:26","slug":"laboratory-of-medical-biology","status":"publish","type":"page","link":"https:\/\/biotech.uwr.edu.pl\/en\/laboratory-of-medical-biology\/","title":{"rendered":"Laboratory of Medical Biology"},"content":{"rendered":"\n<div class=\"wp-block-ugb-container ugb-container blok_nowa_podstrona ugb-8dda971 ugb-container--v2 ugb-container--design-plain ugb-main-block\"><div class=\"ugb-inner-block\"><div class=\"ugb-block-content\"><div class=\"ugb-container__wrapper ugb-8dda971-wrapper\"><div class=\"ugb-container__side\"><div class=\"ugb-container__content-wrapper ugb-8dda971-content-wrapper\">\n<div class=\"wp-block-columns bs-news-page is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column bs-kontakt-photo is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1-1024x683.jpg\" alt=\".\" class=\"wp-image-34704\" srcset=\"https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1-1024x683.jpg 1024w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1-300x200.jpg 300w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1-768x512.jpg 768w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1-1536x1024.jpg 1536w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1-1320x880.jpg 1320w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1-24x16.jpg 24w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1-36x24.jpg 36w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1-48x32.jpg 48w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1.jpg 1600w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">fot. Magdalena Marcula<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column bs-contact-right-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-bonasoft-modular-breadcrumbs-block\"><div class=\"bs_add_breadcrumb_trail\"><\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-black-color has-css-opacity has-black-background-color has-background is-style-wide bs-border-kontakt\"\/>\n\n\n\n<h1 class=\"wp-block-heading bs-naglowek-podstrony\"><strong>Laboratory of Medical Biology<\/strong><\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">HEAD OF THE LABORATORY<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/old.uni.wroc.pl\/en\/search-for-employees\/employee\/?p_id=594847\">Prof. dr hab. Teresa Olczak<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">STAFF<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/old.uni.wroc.pl\/en\/search-for-employees\/employee\/?p_id=599483\">Dr hab. Micha\u0142 \u015amiga<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-ugb-container ugb-container bs-news-page-under ugb-f8694ce ugb-container--v2 ugb-container--design-plain ugb-main-block\"><div class=\"ugb-inner-block\"><div class=\"ugb-block-content\"><div class=\"ugb-container__wrapper ugb-f8694ce-wrapper\"><div class=\"ugb-container__side\"><div class=\"ugb-container__content-wrapper ugb-f8694ce-content-wrapper\">\n<h2 class=\"wp-block-heading\">CONTACT:<\/h2>\n\n\n\n<p>Laboratory: room 3.39, tel. +48 71375 2394<\/p>\n\n\n\n<p>Head: room 3.25, tel. +48 71 375 2612<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">RESEARCH TOPICS AND THE MOST IMPORTANT RESULTS<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Mechanisms of iron and heme acquisition in bacteria \u2013 periodontal diseases and their relationship with human systemic diseases.<\/li>\n<\/ul>\n\n\n\n<p>Periodontal diseases belong to a group of multifactorial, infectious diseases, initiated by an ecological shift in the composition of subgingival biofilm and an exaggerated host immune response towards agents produced by bacteria, which results in inflammation and destruction of tooth-supporting tissues. Recent years brought the emerging evidence of an association between periodontal diseases and systemic diseases, such as diabetes, cardiovascular diseases, Alzheimer\u2019s disease.&nbsp;<em>Porphyromonas gingivalis<\/em>, one of the main etiologic agents and key pathogen responsible for initiation and progression of chronic periodontitis, to survive and initiate infection requires iron and heme, which are acquired by the novel, characterized by our group, Hmu system, with the leading role played by a unique hemophore-like HmuY protein. To increase its own virulence,&nbsp;<em>P. gingivalis<\/em>&nbsp;may also use mechanisms of heme acquisition utilized by other commensal\/pathogenic bacteria, such as&nbsp;<em>Streptococcus gordonii<\/em>,&nbsp;<em>Tannerella forsythia<\/em>,&nbsp;<em>Prevotella intermedia<\/em>, as well as host hemoproteins, which results in dysbiosis in oral microbiome. Moreover, mouth-gut bacterial transmission causes that&nbsp;<em>P. gingivalis<\/em>&nbsp;invading and colonizing the gut is also able to use heme acquisition systems of&nbsp;<em>Bacteroides vulgatus<\/em>&nbsp;and&nbsp;<em>Bacteroides fragilis<\/em>, increasing tendency to cause dysbiosis in the gut microbiome, thus influence the host health through participation in systemic inflammatory diseases.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">TECHNIQUES AND METHODS USED<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Molecular biology techniques (cloning, PCR, RT-PCR, EMSA)<\/li>\n\n\n\n<li>Bacterial cultures (<em>Escherichia coli, Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia,&nbsp;Bacteroides fragilis,&nbsp;Streptococcus gordonii<\/em>)<\/li>\n\n\n\n<li>Mammalian cell cultures<\/li>\n\n\n\n<li>Overexpression and purification of recombinant proteins<\/li>\n\n\n\n<li>Protein purification (chromatographic and electrophoretic methods, low-pressure chromatography, FPLC, HPLC)<\/li>\n\n\n\n<li>Mutagenesis<\/li>\n\n\n\n<li>Spectroscopic methods<\/li>\n\n\n\n<li>Analyses of interactions: protein-protein, protein-heme and protein-DNA<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">EXAMPLE DOCTORAL DISSERTATION TOPICS<\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u201cCharacterization of HmuY lipoprotein from&nbsp;<em>Porphyromonas gingivalis<\/em>\u201c, Halina W\u00f3jtowicz, 2011.<\/li>\n\n\n\n<li>\u201cCharacterization of proteins encoded on the hmu operon in&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;and other bacteria\u201d, Marcin Bielecki, 2015.<\/li>\n\n\n\n<li>\u201cInvolvement of PgFur protein in virulence of&nbsp;<em>Porphyromonas gingivalis<\/em>\u201c, Micha\u0142 \u015amiga, 2018.<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">RESEARCH PROJECTS<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Current<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>NCN OPUS 17 (2019\/33\/B\/NZ6\/00292) \u201cHemophore-like proteins of anaerobic Bacteroidetes \u2013 important virulence factors of key pathogens of human microbiome, related with inflammatory chronic diseases\u201d (2020-2023).<\/li>\n\n\n\n<li>Head of the project: prof. dr hab. Teresa Olczak.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Accomplished<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>NCN OPUS 12 (2016\/23\/B\/NZ6\/00080): \u201cSynergistic mechanisms of heme acquisition used by periodontopathogens under physiological conditions and in periodontal diseases associated with systemic diseases\u201d (2017-2021).<\/li>\n\n\n\n<li>Head of the project: prof. dr hab. Teresa Olczak.<\/li>\n\n\n\n<li>NCN OPUS 9 (2015\/17\/B\/NZ6\/01969): \u201c<em>Porphyromonas gingivalis<\/em>&nbsp;protein and its homologs from other periodontopathogens \u2013 a novel group of bacterial virulence factors\u201d(2016-2019).<\/li>\n\n\n\n<li>Head of the project: prof. dr hab. Teresa Olczak.<\/li>\n\n\n\n<li>NCN OPUS 8 (2014\/15\/B\/NZ6\/01723): \u201cRegulation of mechanisms of iron and heme acquisition and virulence in&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;with involvement of PgFur protein and small RNAs\u201d (2015-2018).<\/li>\n\n\n\n<li>Head of the project: prof. dr hab. Teresa Olczak.<\/li>\n\n\n\n<li>NCN PRELUDIUM 8 (2014\/15\/N\/NZ6\/01718): \u201cCooperation of PgFur with CRISPR-associated proteins and selected transcriptional regulatory factors in mechanisms of&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;virulence\u201d (2015-2018).<\/li>\n\n\n\n<li>Head of the project: dr Micha\u0142 \u015amiga<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">LABORATORY EQUIPMENT<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Anaerobic Workstation<\/li>\n\n\n\n<li>Double-beam spectrophotometer<\/li>\n\n\n\n<li>Fast protein liquid chromatography system<\/li>\n\n\n\n<li>Real-time PCR thermocycler<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">PUBLICATIONS<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Siemi\u0144ska K., Cierpisz P., \u015amiga M., Olczak T. (2021)<em>&nbsp;Porphyromonas gingivalis<\/em>&nbsp;HmuY and&nbsp;<em>Bacteroides vulgatus<\/em>&nbsp;Bvu-a novel competitive heme acquisition strategy.&nbsp;Int J Mol Sci.&nbsp;24;22(5):2237<\/li>\n\n\n\n<li>\u015al\u0119zak P., \u015amiga M., Smalley JW., Siemi\u0144ska K., Olczak T. (2020)&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;HmuY and&nbsp;<em>Streptococcus gordonii<\/em>&nbsp;GAPDH-Novel Heme Acquisition Strategy in the Oral Microbiome. Int J Mol Sci 10;21(11):4150<\/li>\n\n\n\n<li>\u015amiga M., \u015al\u0119zak P., Siemi\u0144ska K., Olczak T. (2020) Mechanizmy wirulencji wykorzystywane w patogenezie chor\u00f3b przyz\u0119bia przez bakterie&nbsp;<em>Porphyromonas gingivalis.&nbsp;<\/em>Postepy Hig Med Dosw&nbsp;74: 247-258<\/li>\n\n\n\n<li>Bielecki M., Antonyuk S., Strange RW., Siemi\u0144ska K., Smalley JW., Mackiewicz P., \u015amiga M., Cowan M., Capper MJ., \u015al\u0119zak P., Olczak M., Olczak T. (2020) Prevotella intermedia produces two proteins homologous to Porphyromonas gingivalis HmuY but with different heme coordination mode. Biochem J. 477(2):381-405<\/li>\n\n\n\n<li>Nobre Dos Santos-Lima EK., Ara\u00fajo Paiva Andrade Cardoso K., Mares de Miranda P., Cirino de Carvalho-Filho P., Passos Rocha T., Ferreira de Moura-Costa L., Olczak T., Miranda Lopes Falc\u00e3o M., Gomes-Filho IS., Meyer R., Tosta Xavier M., Castro Trindade S. (2020) Novel synthetic peptide derived from Porphyromonas gingivalis Lys-gingipain detects IgG-mediated host response in periodontitis. Anaerobe 7(61):102140<\/li>\n\n\n\n<li>\u015amiga M., Olczak T. (2019) PgRsp Is a Novel Redox-Sensing Transcription Regulator Essential for Porphyromonas gingivalis Virulence. Microorganisms 12:623<\/li>\n\n\n\n<li>\u015amiga M., Bielecki M., Olczak M.,&nbsp;Olczak T. (2019)&nbsp;Porphyromonas gingivalis PgFur Is a Member of a Novel Fur Subfamily With Non-canonical Function. Front Cell Infect Microbiol 9:233.<\/li>\n\n\n\n<li>\u015amiga M., St\u0119pie\u0144 P., Olczak M., Olczak T. (2019)&nbsp;PgFur participates differentially in expression of virulence factors in more virulent A7436 and less virulent ATCC 33277 Porphyromonas gingivalis strains.&nbsp;BMC Microbiol&nbsp;19(1):127<\/li>\n\n\n\n<li>Bielecki M., Antonyuk S., Strange R.W., Smalley J.W., Mackiewicz P., \u015amiga M., St\u0119pie\u0144 P., Olczak M., Olczak T. (2018)&nbsp;Tannerella forsythia Tfo belongs to Porphyromonas gingivalis HmuY-like family of proteins but differs in heme-binding properties.&nbsp;Biosci Rep&nbsp;22;38(5).<\/li>\n\n\n\n<li>Brown J.L., Yates E., Bielecki M., Olczak T., Smalley J.W. (2018) Potential role for Streptococcus gordonii-derived hydrogen peroxide in haem acquisition by Porphyromonas gingivalis. Mol Oral Microbiol 33:322-335.<\/li>\n\n\n\n<li>Olczak T., \u015amiga M., Kwiecie\u0144 A., Bielecki M., Wr\u00f3bel R., Olczak M., Ciunik Z. (2017) Antimicrobial activity of stable hemiaminals against&nbsp;<em>Porphyromonas gingivalis<\/em>.&nbsp;Anaerobe. 44:27-33.<\/li>\n\n\n\n<li>Smalley J.W., Olczak T. (2017) Haem acquisition mechanisms of&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;\u2013 strategies used in polymicrobial community in a haem-limited host environment.&nbsp;Mol Oral Microbiol. 32(1):1-23.<\/li>\n\n\n\n<li>Gmiterek A., K\u0142opot A., W\u00f3jtowicz H., Trindade S.C., Olczak M., Olczak T. (2016) Immune response of macrophages induced by&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;requires HmuY protein. Immunobiology 221(12):1382-1394<\/li>\n\n\n\n<li>Carvalho-Filho P.C., Gomes-Filho I.S., Meyer R., Olczak T., Xavier M.T., Trindade S.C. (2016) Role of&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;HmuY in immunopathogenesis of chronic periodontitis. Mediators Inflamm 2016:7465852<\/li>\n\n\n\n<li>Olczak T., Sosicka P., Olczak M. (2015) HmuY is an important virulence factor for&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;growth in the heme-limited host environment and infection of macrophages. Biochem Biophys Res Commun, 2015, 467, 748-753.<\/li>\n\n\n\n<li>Benedyk M., Byrne D.P., Glowczyk I., Potempa J., Olczak M., Olczak T., Smalley J.W. (2015) Pyocyanin, a contributory factor in haem acquisition and virulence enhancement of&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;in the lung. PloS One 10(2):e0118319<\/li>\n\n\n\n<li>\u015amiga M., Bielecki M., Olczak M., Smalley J.W., Olczak T. (2015) Anti-HmuY antibodies specifically recognize&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;HmuY protein but not homologous proteins in other periodontopathogens. PloS One 10(2):e0117508<\/li>\n\n\n\n<li>Ciuraszkiewicz J., \u015amiga M., Mackiewicz P., Gmiterek A., Bielecki M., Olczak M., Olczak T. (2014) Fur homolog regulates&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;virulence under low-iron\/heme conditions through a complex regulatory network. Mol Oral Microbiol 29:333-353<\/li>\n\n\n\n<li>Antonyuk S.V., Olczak M., Olczak T., Ciuraszkiewicz J., Strange R.W. (2014) The structure of a purple acid phosphatase involved in plant growth and pathogen defence exhibits a novel immunoglobulin-like fold. IUCrJ 1:101-109<\/li>\n\n\n\n<li>Gmiterek A., W\u00f3jtowicz H., Mackiewicz P., Radwan-Oczko M., Kantorowicz M., Chomyszyn-Gajewska M., Fr\u0105szczak M., Bielecki M., Olczak M., Olczak T. (2013) The unique hmuY gene sequence as a specific marker of&nbsp;<em>Porphyromonas gingivalis<\/em>. PLoS One 8(7):e67719<\/li>\n\n\n\n<li>Byrne D.P., Potempa J., Olczak T., Smalley J.W. (2013) Evidence of mutualism between two periodontal pathogens: Co-operative haem acquisition by the HmuY haemophore of&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;and the cysteine protease interpain A (InpA) of&nbsp;<em>Prevotella intermedia<\/em>. Mol Oral Microbiol 28:219-229<\/li>\n\n\n\n<li>W\u00f3jtowicz H., Bielecki M., Wojaczy\u0144ski J., Olczak M., Smalley J.W., Olczak T. (2013) The&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;HmuY haemophore binds gallium(iii), zinc(ii), cobalt(iii), manganese(iii), nickel(ii), and copper(ii) protoporphyrin IX but in a manner different to iron(iii) protoporphyrin IX. Metallomics 5:343-351<\/li>\n\n\n\n<li>Wojaczy\u0144ski J., W\u00f3jtowicz H., Bielecki M., Olczak M., Smalley J.W., Latos-Gra\u017cy\u0144ski L., Olczak T. (2011) Iron(III) mesoporphyrin IX and iron(III) deuteroporphyrin IX bind to the&nbsp;<em>Porphyromonas gingivalis<\/em>&nbsp;HmuY hemophore. Biochem Biophys Res Commun 411:299-304<\/li>\n\n\n\n<li>Smalley J.W., Byrne D.P., Birss A.J., Wojtowicz H., Sroka A., Potempa J., Olczak T. (2011) HmuY haemophore and gingipain proteases constitute a unique syntrophic system of haem acquisition by&nbsp;<em>Porphyromonas gingivalis<\/em>. PLoS One 6(2):e17182<\/li>\n\n\n\n<li>W\u00f3jtowicz H., Guevara T., Tallant C., Olczak M., Sroka A., Potempa J., Sol\u00e0 M., Olczak T., Gomis-R\u00fcth F.X. (2009) Unique structure and stability of HmuY, a novel heme-binding protein of&nbsp;<em>Porphyromonas gingivalis<\/em>. PLoS Pathogens 5(5):e1000419<\/li>\n<\/ol>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Laboratory of Medical Biology HEAD OF THE LABORATORY STAFF CONTACT: Laboratory: room 3.39, tel. +48 71375 2394 Head: room 3.25, tel. +48 71 375 2612 RESEARCH TOPICS AND THE MOST IMPORTANT RESULTS Periodontal diseases belong to a group of multifactorial, infectious diseases, initiated by an ecological shift in the composition of subgingival biofilm and an [&hellip;]<\/p>\n","protected":false},"author":20,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[],"tags":[],"class_list":["post-36067","page","type-page","status-publish","hentry"],"featured_image_urls_v2":{"full":"","thumbnail":"","medium":"","medium_large":"","large":"","1536x1536":"","2048x2048":"","menu-24x24":"","menu-36x36":"","menu-48x48":""},"post_excerpt_stackable_v2":"<p>fot. Magdalena Marcula Laboratory of Medical Biology HEAD OF THE LABORATORY Prof. dr hab. Teresa Olczak STAFF Dr hab. Micha\u0142 \u015amiga CONTACT: Laboratory: room 3.39, tel. +48 71375 2394 Head: room 3.25, tel. +48 71 375 2612 RESEARCH TOPICS AND THE MOST IMPORTANT RESULTS Mechanisms of iron and heme acquisition in bacteria \u2013 periodontal diseases and their relationship with human systemic diseases. Periodontal diseases belong to a group of multifactorial, infectious diseases, initiated by an ecological shift in the composition of subgingival biofilm and an exaggerated host immune response towards agents produced by bacteria, which results in inflammation and destruction&hellip;<\/p>\n","category_list_v2":"Uncategorized","author_info_v2":{"name":"mmatlinski","url":"https:\/\/biotech.uwr.edu.pl\/en\/author\/mmatlinski\/"},"comments_num_v2":"0 comments","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Laboratory of Medical Biology - Wydzia\u0142 Biotechnologii<\/title>\n<meta name=\"description\" content=\"Wydzia\u0142 Biotechnologii\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biotech.uwr.edu.pl\/en\/laboratory-of-medical-biology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Laboratory of Medical Biology - 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