{"id":36034,"date":"2022-06-24T18:11:53","date_gmt":"2022-06-24T16:11:53","guid":{"rendered":"https:\/\/biotech.uwr.edu.pl\/zaklad-biotransformacjii\/"},"modified":"2025-11-27T14:24:03","modified_gmt":"2025-11-27T13:24:03","slug":"department-of-biotransformation","status":"publish","type":"page","link":"https:\/\/biotech.uwr.edu.pl\/en\/department-of-biotransformation\/","title":{"rendered":"Department of Biotransformation"},"content":{"rendered":"\n<div class=\"wp-block-ugb-container ugb-container blok_nowa_podstrona ugb-8dda971 ugb-container--v2 ugb-container--design-plain ugb-main-block\"><div class=\"ugb-inner-block\"><div class=\"ugb-block-content\"><div class=\"ugb-container__wrapper ugb-8dda971-wrapper\"><div class=\"ugb-container__side\"><div class=\"ugb-container__content-wrapper ugb-8dda971-content-wrapper\">\n<div class=\"wp-block-columns bs-news-page is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column bs-kontakt-photo is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1600\" height=\"1067\" src=\"https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6.jpg\" alt=\".\" class=\"wp-image-34812\" srcset=\"https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6.jpg 1600w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-300x200.jpg 300w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1024x683.jpg 1024w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-768x512.jpg 768w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1536x1024.jpg 1536w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1320x880.jpg 1320w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-24x16.jpg 24w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-36x24.jpg 36w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-48x32.jpg 48w\" sizes=\"auto, (max-width: 1600px) 100vw, 1600px\" \/><figcaption class=\"wp-element-caption\">fot. Magdalena Marcula<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column bs-contact-right-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-bonasoft-modular-breadcrumbs-block\"><div class=\"bs_add_breadcrumb_trail\"><\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-black-color has-css-opacity has-black-background-color has-background is-style-wide bs-border-kontakt\"\/>\n\n\n\n<h1 class=\"wp-block-heading bs-naglowek-podstrony\"><strong>Department of Biotransformation<\/strong><\/h1>\n\n\n\n<h3 class=\"wp-block-heading\">DEPARTMENT HEAD<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/old.uni.wroc.pl\/en\/search-for-employees\/employee\/?p_id=588002\" target=\"_blank\" rel=\"noreferrer noopener\">Dr hab. Dorota Dziadkowiec<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">STAFF MEMBERS<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/old.uni.wroc.pl\/en\/search-for-employees\/employee\/?p_id=595676\" target=\"_blank\" rel=\"noreferrer noopener\">Prof. dr hab. Marcin \u0141ukaszewicz<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/old.uni.wroc.pl\/en\/search-for-employees\/employee\/?p_id=587834\" target=\"_blank\" rel=\"noreferrer noopener\">Dr hab. Anna Krasowska, prof. UWr<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/old.uni.wroc.pl\/en\/search-for-employees\/employee\/?p_id=597496\" target=\"_blank\" rel=\"noreferrer noopener\">Dr S\u0142awomir Jab\u0142o\u0144ski<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/old.uni.wroc.pl\/en\/search-for-employees\/employee\/?p_id=710534\" target=\"_blank\" rel=\"noreferrer noopener\">Dr Daria Derkacz<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/old.uni.wroc.pl\/en\/search-for-employees\/employee\/?p_id=709126\">Mgr B\u0142a\u017cej Przystajko<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-ugb-container ugb-container bs-news-page-under ugb-f8694ce ugb-container--v2 ugb-container--design-plain ugb-main-block\"><div class=\"ugb-inner-block\"><div class=\"ugb-block-content\"><div class=\"ugb-container__wrapper ugb-f8694ce-wrapper\"><div class=\"ugb-container__side\"><div class=\"ugb-container__content-wrapper ugb-f8694ce-content-wrapper\">\n<h3 class=\"wp-block-heading\">PhD Students<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>mgr Micha\u0142 Bochynek | room: 2.21, Tel: +48 71375 7062&nbsp;<\/li>\n\n\n\n<li>mgr Dorota Misiorna | room: 2.21, Tel: +48 71375 7062&nbsp;<\/li>\n\n\n\n<li>mgr Liliana Cebula | room: 2.23, Tel: +48 71375 7976<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">CONTACT<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Head: dr hab. Dorota Dziadkowiec | room: 2.20, Tel: +48 71375 6238<\/li>\n\n\n\n<li>prof. dr hab. in\u017c. Marcin \u0141ukaszewicz | room: 2.19, Tel: +48 71375 6250&nbsp;<\/li>\n\n\n\n<li>dr hab. Anna Krasowska | room:&nbsp;2.18, Tel:&nbsp;+48 71375 6426&nbsp;<\/li>\n\n\n\n<li>dr S\u0142awomir Jab\u0142o\u0144ski | room: 2.21, Tel: +48 71375 7062&nbsp;<\/li>\n\n\n\n<li>dr Daria Derkacz | room: 2.23, Tel: +48 71375 7976&nbsp;<\/li>\n\n\n\n<li>mgr Filip Kot | room: 2.21, Tel: +48 71375 7062&nbsp;<\/li>\n\n\n\n<li>mgr B\u0142a\u017cej Przystajko | room: 2.21, Tel: +48 71375 7062<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">RESEARCH TOPICS<\/h2>\n\n\n\n<p>Research conducted at the Department of Biotransformation is focused on several main areas, in three research teams<\/p>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-8e882a9 is-style-default\" data-block-id=\"8e882a9\">\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-c7b1a97 stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"c7b1a97\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-c7b1a97-container stk-hover-parent\"><div class=\"stk-block-content stk-inner-blocks stk-c7b1a97-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-6fb6d89\" data-block-id=\"6fb6d89\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-a1a2837\" id=\"pro-span-style-color-var-ast-global-color-0-class-stk-highlight-dorota-dziadkowiec-research-team-span\" data-block-id=\"a1a2837\"><h4 class=\"stk-block-heading__text\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">DR HAB. DOROTA DZIADKOWIEC RESEARCH TEAM<\/span><\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-1d96c77\" data-block-id=\"1d96c77\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-1d96c77\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-1-d-96-c-77-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-1-d-96-c-77-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-c263e2c stk-block-accordion__content\" data-v=\"4\" data-block-id=\"c263e2c\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-c263e2c-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-c263e2c-inner-blocks\">\n<h3 class=\"wp-block-heading has-text-align-center\"><span style=\"color: #35ae82;\" class=\"stk-highlight\">The role of homologous recombination mediators in DNA replication and repair and maintaining genome integrity&nbsp;<\/span><br><span style=\"color: #35ae82;\" class=\"stk-highlight\">in <em>Schizosaccharomyces pombe<\/em> and <em>Saccharomyces cerevisiae<\/em>.<\/span><\/h3>\n\n\n\n<p>Homologous recombination is a very important mechanism that allows the exchange of genetic material between homologous sequences. It is involved in processes such as repair of double-strand DNA breaks, activation of stalled replication forks, and is important for maintaining the structure of telomeres and centromeres. Therefore, it plays a very important role in maintaining genome stability, crucial for prevention of cancer development in higher organisms.<\/p>\n\n\n\n<p>We study two proteins in <em>Schizosaccharomyces pombe<\/em>, Rrp1 and Rrp2, that are involved in homologous recombination. They belong, together with the <em>Saccharomyces cerevisiae <\/em>paralog, Uls1, to a class of DNA-dependent translocases that connect two very important pathways of post-translational protein modifications\u2013 SUMOylation and ubiquitination, important for protein degradation, but also regulating their localisation, binding partners and activity.<\/p>\n\n\n\n<p>We have shown that Uls1, as well as Rrp1 and Rrp2, is involved in the response to replication stress and regulate the choice of the repair pathway for damaged DNA. Uls1 and Rrp2 also play a role in stabilizing the structure of telomeres. Recently, we have shown that Rrp1 and Rrp2 modulate the balance between histone variants on chromatin, which is important for the proper functioning of the centromere. The functions of Uls1, Rrp1 and Rrp2 depend on the SUMO interaction motifs, the ATPase domain characteristic of translocases, and the RING domain characteristic of ubiquitin ligases, present in their structure.<\/p>\n\n\n\n<p>We have shown directly, on a purified protein preparation, that Rrp1 regulates the activity of Rad51 recombinase, because it ubiquitylates it and removes it from double-stranded DNA.<\/p>\n\n\n\n<p>We are currently investigating, using fluorescence microscopy and immunoprecipitation, the interactions of Rrp1 and Rrp2 proteins with other proteins involved in maintaining genome stability. We also examine, using mass spectrometry, which proteins are ubiquitylated and SUMOylated in a Rrp1- and Rrp2-dependent manner.<\/p>\n\n\n\n<p>Principal investigator: <span style=\"color: #35ae82;\" class=\"stk-highlight\">dr hab. Dorota Dziadkowiec<\/span><br>PhD students:<br><span style=\"color: #35ae82;\" class=\"stk-highlight\">Dorota Misiorna<\/span> &#8211; SUMOylation and SUMO-dependent enzymes in response to replication stress in yeast. Co-supervisor: dr Karol Kramarz.<br><span style=\"color: #35ae82;\" class=\"stk-highlight\">dr Gabriela Baranowska<\/span> &#8211; The role of DNA-dependent translocases in maintaining genome stability in <em>Schizosaccharomyces pombe<\/em>. Completed in 2024.|<br><span style=\"color: #35ae82;\" class=\"stk-highlight\">dr Jakub Muraszko<\/span> &#8211; Rrp1 translocase as a regulator of Rad51 recombinase function in <em>Schizosaccharomyces pombe<\/em>. Completed in 2021.<br><span style=\"color: #35ae82;\" class=\"stk-highlight\">dr Anna Barg<\/span>&#8211;<span style=\"color: #35ae82;\" class=\"stk-highlight\">Wojas<\/span> &#8211; The role of homologous recombination mediators in maintaining the integrity of <em>Schizosaccharomyces pombe<\/em> centromeres. Completed in 2019.<br><span style=\"color: #35ae82;\" class=\"stk-highlight\">dr Karol Kramarz<\/span> &#8211; The role of Rad5 orthologues in DNA repair in yeasts <em>Saccharomyces cerevisiae<\/em> and <em>Schizosaccharomyces pombe<\/em>. Completed in 2016.<\/p>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-fc401f1 is-style-plain\" data-block-id=\"fc401f1\"><style>.stk-fc401f1 {border-style:solid !important;border-color:#dfdad1 !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:1px !important;border-left-width:0px !important;padding-bottom:24px !important;}<\/style>\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-e83b98c stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"e83b98c\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-e83b98c-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-e83b98c-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-f707eb4\" data-block-id=\"f707eb4\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-23429a9\" id=\"publica\" data-block-id=\"23429a9\"><h4 class=\"stk-block-heading__text\">PUBLICATIONS<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-9155405\" data-block-id=\"9155405\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-9155405\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-9155405-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-9155405-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-2e53633 stk-block-accordion__content\" data-v=\"4\" data-block-id=\"2e53633\"><style>.stk-2e53633-container{padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-2e53633-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-2e53633-inner-blocks\">\n<h3 class=\"wp-block-heading\">Latest publications:<\/h3>\n\n\n\n<p>Baranowska G., Misiorna D., Bia\u0142ek W., Kramarz K., Dziadkowiec D., <em>PLoS One<\/em>, 2024<br><a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0300434\" target=\"_blank\" rel=\"noreferrer noopener\">Replication stress response in fission yeast differentially depends on maintaining proper levels of Srs2 helicase and Rrp1, Rrp2 DNA translocases<\/a>.<\/p>\n\n\n\n<p>Kramarz K., Dziadkowiec D., <em>DNA Repair (Amst)<\/em>., 2022<br><a href=\"https:\/\/doi.org\/10.1016\/j.dnarep.2022.103356\" target=\"_blank\" rel=\"noreferrer noopener\">Rrp1, Rrp2 and Uls1 &#8211; Yeast SWI2\/SNF2 DNA dependent translocases in genome stability maintenance<\/a>.<\/p>\n\n\n\n<p>Muraszko J., Kramarz K., Argunhan B., Ito K., Baranowska G., Kurokawa Y., Murayama Y., Tsubouchi H., Lambert S., Iwasaki H., Dziadkowiec D., <em>Nucleic Acids Res<\/em>., 2021<br><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkab511\" target=\"_blank\" rel=\"noreferrer noopener\">Rrp1 translocase and ubiquitin ligase activities restrict the genome destabilising effects of Rad51 in fission yeast<\/a>.<\/p>\n\n\n\n<p>Barg-Wojas A., Muraszko J., Kramarz K., Schirmeisen K., Baranowska G., Carr AM., Dziadkowiec D., <em>J Cell Sci<\/em>., 2020<br><a href=\"https:\/\/doi.org\/10.1242\/jcs.230193\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Schizosaccharomyces pombe<\/em> DNA translocases Rrp1 and Rrp2 have distinct roles at centromeres and telomeres that ensure genome stability<\/a>.<br><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Dziadkowiec%2C+Dorota%5BAuthor%5D&amp;sort=pubdate\" target=\"_blank\" rel=\"noreferrer noopener\">Other publications<\/a><\/h3>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-42744c6 is-style-plain\" data-block-id=\"42744c6\"><style>.stk-42744c6 {border-style:solid !important;border-color:#dfdad1 !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:1px !important;border-left-width:0px !important;padding-bottom:24px !important;}<\/style>\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-1ad678c stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"1ad678c\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-1ad678c-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-1ad678c-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-10c5c76\" data-block-id=\"10c5c76\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-3aedea8\" id=\"przykladowe-tematy-prac-magister-selected-topics-of-masters-thesesh\" data-block-id=\"3aedea8\"><h4 class=\"stk-block-heading__text\">SELECTED TOPICS OF MASTER&#8217;S THESIS<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-dfcf067\" data-block-id=\"dfcf067\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-dfcf067\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-dfcf-067-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-dfcf-067-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-9f18a88 stk-block-accordion__content\" data-v=\"4\" data-block-id=\"9f18a88\"><style>.stk-9f18a88-container{padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-9f18a88-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-9f18a88-inner-blocks\">\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-255e474\" data-block-id=\"255e474\"><p class=\"stk-block-text__text\">Regulation of Rad51 recombinase during DNA replication &#8211; the role of Srs2 in <em>Schizosaccharomyces pombe<\/em>.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-f96fee0 is-style-plain\" data-block-id=\"f96fee0\"><style>.stk-f96fee0 {border-style:solid !important;border-color:#dfdad1 !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:1px !important;border-left-width:0px !important;padding-bottom:24px !important;}<\/style>\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-20ba84b stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"20ba84b\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-20ba84b-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-20ba84b-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-472ded2\" data-block-id=\"472ded2\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-d9615b8\" id=\"selected-topics-of-bachelorss-thesis\" data-block-id=\"d9615b8\"><h4 class=\"stk-block-heading__text\">SELECTED TOPICS OF BACHELORS&#8217;S THESIS<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-d3b6fb2\" data-block-id=\"d3b6fb2\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-d3b6fb2\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-d-3-b-6-fb-2-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-d-3-b-6-fb-2-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-9060a3d stk-block-accordion__content\" data-v=\"4\" data-block-id=\"9060a3d\"><style>.stk-9060a3d-container{padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-9060a3d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-9060a3d-inner-blocks\">\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-3af52a6\" data-block-id=\"3af52a6\"><p class=\"stk-block-text__text\">Social behaviour of <em>Myxococcus xanthus<\/em> bacteria.<\/p><\/div>\n\n\n\n<p>The role of <em>Borrelia sp<\/em>. virulence factors in the course of infection.<\/p>\n<\/div><\/div><\/div>\n<\/details>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-19a5377 is-style-default\" data-block-id=\"19a5377\">\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4bb7885 stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"4bb7885\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4bb7885-container stk-hover-parent\"><div class=\"stk-block-content stk-inner-blocks stk-4bb7885-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-bdfb0c5\" data-block-id=\"bdfb0c5\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-beb3730\" id=\"zespol-dr\" data-block-id=\"beb3730\"><h4 class=\"stk-block-heading__text\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">DR HAB. ANNA KRASOWSKA, PROF. UWR<\/span> <span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">RESEARCH TEAM<\/span><\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-4db52d2\" data-block-id=\"4db52d2\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-4db52d2\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-4-db-52-d-2-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-4-db-52-d-2-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-18caaf1 stk-block-accordion__content\" data-v=\"4\" data-block-id=\"18caaf1\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-18caaf1-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-18caaf1-inner-blocks\">\n<p>The research group of dr hab. Anna Krasowska, prof. UWr focuses on the analysis of the impact of changes in the cell membrane of the pathogenic fungus <em>Candida albicans<\/em> on its morphology, metabolism, virulence and multidrug resistance.<\/p>\n\n\n\n<p>According to the fungal priority pathogens list (FPPL) which pose the greatest threat to public health, published in the report of the World Health Organization (WHO) from the end of 2022 (<em>WHO fungal priority pathogens list to guide research, development and public health action<\/em>), C. albicans are in the group of pathogens with the highest priority. The classification of this microorganism into the group of the most dangerous fungal pathogens is due to the frequent occurrence of infections worldwide, a high rate of deaths due to systemic mycoses (disseminated candidiasis) and the lack of effective antifungal therapies (occurrence of multidrug resistance of <em>C. albicans<\/em>).<\/p>\n\n\n\n<p>Taking into account the above aspects, searching for new antibiotics and therapies that can effectively combat fungal infections is pivotal. The aim of most drugs used in medicine is the biosynthesis of ergosterol or directly this molecule present in the fungal cell membrane (respectively: azoles, polyenes). The above groups of drugs use one of the few differences between fungal cells (presence of ergosterol) and host cells (presence of cholesterol).<\/p>\n\n\n\n<p>In our research group, we analyze the effect of these drugs on the lipid composition of cell membranes, the location and activity of membrane transporters responsible for the ejection of drugs from the fungal cell, and the expression of genes encoding key adhesins and invasins (proteins responsible for the first stages of fungal infection). We also have an extensive collection of strains with mutations in genes encoding enzymes of the ergosterol biosynthesis pathway (deletion of key genes, replacement of amino acids in the Erg11 protein sequence), which constitute a valuable model in studies on multidrug resistance of <em>C. albicans<\/em>.<\/p>\n\n\n\n<p>In addition to antibiotics already used in medicine, we are also looking for compounds of natural origin that exhibit antifungal activity, which can be used in the treatment of infections separately or in parallel with conventional therapies. In our research team, we study the effect of such compounds on the survival and morphology of <em>C. albicans<\/em> cells, such as: capric acid, lactic acid or clove extracts.<\/p>\n\n\n\n<p>The team&#8217;s latest projects concern the analysis of the role of sphingolipids in <em>C. albicans<\/em> resistance to antifungal drugs, virulence and inflammatory and cellular response of human cell lines. Sphingolipids are lipid molecules present next to ergosterol in the fungal cell membrane and are responsible for signal transduction, proper structure of the cell membrane, and the formation of microdomains. Recent studies indicate that sphingolipids also play a role in the occurrence of resistance to antifungal drugs, and modification of sphingolipid biosynthesis pathways can lead to an altered structure of the cell wall and, consequently, recognition of the pathogen by the immune system. In addition, <em>C. albicans<\/em> has the ability to mask PAMP molecules from the host&#8217;s immune system by modifying the structure of the cell wall (cell wall remodeling). In the project carried out by our team, we analyze the impact of changes in sphingolipid biosynthesis on the structure and composition of the membrane and cell wall, inflammatory and cellular response of human cell lines.<\/p>\n\n\n\n<p><em>C. albicans<\/em> is an opportunistic pathogen. This means that infections caused by it develop during host immunity deficiencies. For this reason, interactions between the fungus and the host organism in the context of the immune response are also interesting.<\/p>\n\n\n\n<p>The project carried out by dr Daria Derkacz analyzes the impact of changes in \u03b2-glucan biosynthesis (a key PAMP molecule, pathogen-associated molecular pattern), present in the cell wall of the fungus <em>C. albicans<\/em>, on the inflammatory and cellular response of vaginal epithelial cell lines and gingival fibroblasts. It was found that the lack or increase in the amount of ergosterol in the fungal cell membrane causes a change in the structure of the cell wall, leading to the exposure of \u03b2-glucan and chitin on the cell surface. This may contribute to differences in the recognition of the pathogen by PRRs (pathogen recognition receptors) on host cells and, consequently, to an altered immune response.PhD thesis:<\/p>\n\n\n\n<p>PhD thesis:<\/p>\n\n\n\n<p><span style=\"color: #35ae82;\" class=\"stk-highlight\">Liliana Cebula<\/span> &#8211; \u201e<em>Changes in the structure of the Candida albicans plasma membrane and cell wall on the inflammatory and cellular immune response\u201d<\/em>. In progress (since 2024), Co-supervisor: dr Daria Derkacz.<br><span style=\"color: #35ae82;\" class=\"stk-highlight\">dr Daria Derkacz<\/span> &#8211; \u201e<em>The role of the Candida albicans plasma membrane and cell wall in the inflammatory response<\/em>\u201d. Defense 2024 \u2013 distinction.<br><span style=\"color: #35ae82;\" class=\"stk-highlight\">dr Jakub Suchodolski<\/span> &#8211; \u201e<em>The effect of ergosterol on the activity of the Cdr1 transporter and selected parameters of the plasma membrane in Candida albicans<\/em>\u201d. Defense 2020 \u2013 distinction.<br><span style=\"color: #35ae82;\" class=\"stk-highlight\">dr Joanna Szczepaniak<\/span> &#8211; \u201e<em>The effect of selected factors on the activity of Candida albicans ABC transporters<\/em>\u201d. Defense 2017 \u2013 distinction.<br><span style=\"color: #35ae82;\" class=\"stk-highlight\">dr Anna Pawluk (Murzyn<\/span>) &#8211; \u201e<em>The effect of Saccharomyces boulardii on the virulence factors of C. albicans<\/em>\u201d. Defense 2010 \u2013 distinction.<br><span style=\"color: #35ae82;\" class=\"stk-highlight\">dr Ida Szmigiel<\/span> \u2013 \u201e<em>Biotransformation of rapeseed meal using Bacillus subtilis<\/em>\u201d. Defense 2021 \u2013 distinction.<br><span style=\"color: #35ae82;\" class=\"stk-highlight\">dr Damian Konkol<\/span> \u2013 \u201e<em>Use of biotransformed rapeseed meal in poultry nutrition<\/em>\u201d. Defense 2022 \u2013 distinction.<\/p>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-d947cf7 is-style-plain\" data-block-id=\"d947cf7\"><style>.stk-d947cf7 {border-style:solid !important;border-color:#dfdad1 !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:1px !important;border-left-width:0px !important;padding-bottom:24px !important;}<\/style>\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-51d52f0 stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"51d52f0\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-51d52f0-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-51d52f0-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-61d2cb1\" data-block-id=\"61d2cb1\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-7c568b5\" id=\"pr-esearch-projec-tojekty-badawcze\" data-block-id=\"7c568b5\"><h4 class=\"stk-block-heading__text\">RESEARCH PROJECTS<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-f14983c\" data-block-id=\"f14983c\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-f14983c\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-f-14983-c-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-f-14983-c-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4cc6007 stk-block-accordion__content\" data-v=\"4\" data-block-id=\"4cc6007\"><style>.stk-4cc6007-container{padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4cc6007-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-4cc6007-inner-blocks\">\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-6a5325b\" data-block-id=\"6a5325b\"><p class=\"stk-block-text__text\">Project NCN MINIATURA 8, 2024\/08\/X\/N21\/00702: &#8220;<em>Isolation and determination of the structure of \u03b2-glucan obtained from the cell wall of Candida albicans strains with impaired ergosterol synthesis and assessment of the effect of \u03b2-glucan on the inflammatory and cellular response<\/em>&#8220;, (2024-present).<br>Project manager: dr Daria Derkacz.<\/p><\/div>\n\n\n\n<p>Project NCN OPUS 22, 2021\/43\/B\/NZ1\/00523: &#8220;<em>The role of Candida albicans plasma membrane sphingolipids in a potentially new mechanism of drug resistance and inflammatory response<\/em>&#8220;, (2022-present).<br>Project manager: dr hab. Anna Krasowska, prof. UWr.<\/p>\n\n\n\n<p>Project NCN PRELUDIUM, 2017\/25\/N\/NZ1\/00050: &#8220;<em>The role of fructose in multidrug resistance of Candida albicans<\/em>&#8220;, (2018-2021).<br>Project manager: dr Jakub Suchodolski.<\/p>\n\n\n\n<p>Project NCN OPUS 12, 2016\/23\/B\/NZ1\/01928: &#8220;<em>Changes in drug resistance and virulence of Candida albicans in the presence of different carbon sources<\/em>&#8220;, (2017-2021).<br>Project manager: dr hab. Anna Krasowska, prof. UWr.<\/p>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-e541a7c is-style-plain\" data-block-id=\"e541a7c\"><style>.stk-e541a7c {border-style:solid !important;border-color:#dfdad1 !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:1px !important;border-left-width:0px !important;padding-bottom:24px !important;}<\/style>\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-a1055ea stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"a1055ea\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-a1055ea-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-a1055ea-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-1020970\" data-block-id=\"1020970\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-6c896e1\" id=\"publications\" data-block-id=\"6c896e1\"><h4 class=\"stk-block-heading__text\">PUBLICATIONS<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-33da8d4\" data-block-id=\"33da8d4\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-33da8d4\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-33-da-8-d-4-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-33-da-8-d-4-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-d97e32d stk-block-accordion__content\" data-v=\"4\" data-block-id=\"d97e32d\"><style>.stk-d97e32d-container{padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-d97e32d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-d97e32d-inner-blocks\">\n<h3 class=\"wp-block-heading\">Latest publications:<\/h3>\n\n\n\n<p>Derkacz D., Grzybowska M., Cebula L. and Krasowska A., (2023) Int. J. Mol. Sci, 24(24), 17499<br><a href=\"https:\/\/doi.org\/10.3390\/ijms242417499\" target=\"_blank\" rel=\"noreferrer noopener\">Surfactin and capric acid affects the posaconazole susceptibility of <em>Candida albicans<\/em> strains with altered sterols and sphingolipids biosynthesis.<\/a><\/p>\n\n\n\n<p>Sztafrowski D., Muraszko J., Jasiura A., Bryk P., Urbanek A.K. and Krasowska A., (2023), PloS One<a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0291438\" target=\"_blank\" rel=\"noreferrer noopener\">The alternating 50 Hz magnetic field depending on the hydrophobicity of the strain affects the viability, filamentation and sensitivity to drugs of <em>Candida albicans<\/em>.<\/a><\/p>\n\n\n\n<p>Starosta R., de Almeida R.F.M., Suchodolski J., Derkacz D., Krasowska A., (2023), Journal of Inorganic Biochemistry<br><a href=\"https:\/\/doi.org\/10.1016\/j.jinorgbio.2023.112355\" target=\"_blank\" rel=\"noreferrer noopener\">Anticandidal Cu(I) Complexes with Neocuproine and 1-(4-Methoxyphenyl)Piperazine Based Diphenylaminomethylphosphine: Is Cu-Diimine Moiety a Pharmacophore?<\/a><\/p>\n\n\n\n<p>Derkacz D. and Krasowska A., (2023), Int. J. Mol. Sci., 24, 3966<br><a href=\"https:\/\/doi.org\/10.3390\/ijms24043966\" target=\"_blank\" rel=\"noreferrer noopener\">Alterations in the level of ergosterol in <em>Candida albicans\u2019<\/em> plasma membrane correspond with changes in virulence and result in triggering diversed inflammatory response.<\/a><\/p>\n\n\n\n<p>Urbanek A.K., \u0141api\u0144ska Z., Derkacz D. and Krasowska A., (2022) Pathogens, 11, 1289<br><a href=\"https:\/\/doi.org\/10.3390\/pathogens11111289\" target=\"_blank\" rel=\"noreferrer noopener\">The role of ERG11 point mutations in the resistance of <em>Candida albicans<\/em> to fluconazole in the presence of lactate.<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Other Publications<\/h3>\n\n\n<div class=\"bs__links\">\r\n    <div class=\"bs__links__section\">\r\n        <ul class=\"bs__links__list\">\r\n                            <li class=\"bs__links__list__item\">\r\n                    <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28krasowska%2C+anna%5BAuthor%5D%29+OR+%28Derkacz%2C+Daria%5BAuthor%5D%29&#038;sort=pubdate\" class=\"bs__links__list__item__link\">\r\n                        PubMed \r\n                        <div class=\"bs__links__list__item__link__before__icon\">\r\n                            <div class=\"bs__links__list__item__link__icon\">\r\n                                <svg width=\"40px\" height=\"40px\" viewBox=\"0 0 22 16\" version=\"1.1\">\r\n                                <g stroke=\"none\" strokeWidth=\"1\" fill=\"black\" fillRule=\"evenodd\">\r\n                                    <g>\r\n                                    <polygon points=\"13.4875 0 12 1.6215 18.7875 8 12 14.3795 13.4875 16 21.9995 8\" \/>\r\n                                    <\/g>\r\n                                <\/g>\r\n                                <\/svg>\r\n                            <\/div>\r\n                        <\/div>\r\n                    <\/a>\r\n                <li>\r\n                            <li class=\"bs__links__list__item\">\r\n                    <a href=\"https:\/\/scholar.google.com\/citations?user=3ZOhSSsAAAAJ&#038;hl=pl&#038;oi=ao\" class=\"bs__links__list__item__link\">\r\n                        Google Scholar \r\n                        <div class=\"bs__links__list__item__link__before__icon\">\r\n                            <div class=\"bs__links__list__item__link__icon\">\r\n                                <svg width=\"40px\" height=\"40px\" viewBox=\"0 0 22 16\" version=\"1.1\">\r\n                                <g stroke=\"none\" strokeWidth=\"1\" fill=\"black\" fillRule=\"evenodd\">\r\n                                    <g>\r\n                                    <polygon points=\"13.4875 0 12 1.6215 18.7875 8 12 14.3795 13.4875 16 21.9995 8\" \/>\r\n                                    <\/g>\r\n                                <\/g>\r\n                                <\/svg>\r\n                            <\/div>\r\n                        <\/div>\r\n                    <\/a>\r\n                <li>\r\n                    <\/ul>\r\n    <\/div>\r\n<\/div><\/div><\/div><\/div>\n<\/details>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-6aea45f is-style-plain\" data-block-id=\"6aea45f\"><style>.stk-6aea45f {border-style:solid !important;border-color:#dfdad1 !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:1px !important;border-left-width:0px !important;padding-bottom:24px !important;}<\/style>\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-28b817a stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"28b817a\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-28b817a-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-28b817a-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-32dbb98\" data-block-id=\"32dbb98\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-0f81b4b\" id=\"exa-topics-of-masters-theses\" data-block-id=\"0f81b4b\"><h4 class=\"stk-block-heading__text\">EXAMPLES OF MASTER&#8217;S THESIS TOPICS<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-b68405c\" data-block-id=\"b68405c\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-b68405c\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-b-68405-c-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-b-68405-c-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-e6490da stk-block-accordion__content\" data-v=\"4\" data-block-id=\"e6490da\"><style>.stk-e6490da-container{padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-e6490da-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-e6490da-inner-blocks\">\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-e2baec4\" data-block-id=\"e2baec4\"><p class=\"stk-block-text__text\">1. The effect of selected plant extracts on <em>Candida albicans<\/em>.<\/p><\/div>\n\n\n\n<p>2. Synergistic effect of posaconazole and capric acid on selected <em>Candida albicans<\/em> strains.<\/p>\n\n\n\n<p>3. The effect of factors changing the <em>Candida albicans<\/em> cell wall on the survival of this fungus.<\/p>\n\n\n\n<p>4. Synergistic activity of posaconazole with selected compounds against <em>Candida albicans<\/em>.<\/p>\n\n\n\n<p>5. Analysis of the effect of caspofungin on the morphology of <em>Candida albicans<\/em> cells and the effect on the inflammatory response of human cell lines.<\/p>\n<\/div><\/div><\/div>\n<\/details>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-eb782c9 is-style-default\" data-block-id=\"eb782c9\">\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-a67aab9 stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"a67aab9\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-a67aab9-container stk-hover-parent\"><div class=\"stk-block-content stk-inner-blocks stk-a67aab9-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-cb0fd2a\" data-block-id=\"cb0fd2a\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-e945376\" id=\"zespol-dr\" data-block-id=\"e945376\"><h4 class=\"stk-block-heading__text\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">PROF. DR HAB. IN\u017b. MARCIN \u0141UKASZEWICZ RESEARCH TEAM<\/span><\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-aaf63da\" data-block-id=\"aaf63da\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-aaf63da\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-aaf-63-da-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-aaf-63-da-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-20c90e5 stk-block-accordion__content\" data-v=\"4\" data-block-id=\"20c90e5\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-20c90e5-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-20c90e5-inner-blocks\">\n<h3 class=\"wp-block-heading\"><span style=\"color: #35ae82;\" class=\"stk-highlight\">Isolation and Characterization of Biosurfactants<\/span><\/h3>\n\n\n\n<p>Some microorganisms\u2014bacteria, yeasts, and fungi\u2014produce surface-active compounds known as biosurfactants. These compounds vary in chemical structure, including low-molecular-weight types such as glycolipids, lipopeptides, and cyclic peptides, as well as high-molecular-weight types like lipopolysaccharides, biopolymer complexes, and lipoproteins.<\/p>\n\n\n\n<p>In the Department of Biotransformation, several bacteria and fungi have been isolated from water and soil samples from Spitsbergen. These microorganisms belong to the group of psychrotolerants and do not grow at temperatures above 30\u00b0C. They exhibit a wide range of metabolic capabilities, including the secretion of biosurfactants into their environment.<\/p>\n\n\n\n<p>The chemical structure of a biosurfactant, named pseudofactin, secreted by the Arctic strain <em>Pseudomonas fluorescens<\/em> BD5, has been identified. It is a lipopeptide that reduces surface tension from 72 mN\/m to 31.5 mN\/m at a concentration of 72 mg\/L. The stability and emulsification index of pseudofactin are higher than those of Tween 20 and Triton X-100.<\/p>\n\n\n\n<p>Additionally, pseudofactin has been found to exhibit anti-adhesive properties against uropathogenic microorganisms. The studied biosurfactant prevents microbial adhesion to glass, plastic, and silicone surfaces. Furthermore, it removes already-formed biofilms from these surfaces.<\/p>\n\n\n\n<p>The research conducted at the Department of Biotransformation aims to identify new applications for biosurfactants and to develop efficient industrial-scale production technologies.<\/p>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-e61caf0 is-style-plain\" data-block-id=\"e61caf0\"><style>.stk-e61caf0 {border-style:solid !important;border-color:#dfdad1 !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:1px !important;border-left-width:0px !important;padding-bottom:24px !important;}<\/style>\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-a840a9e stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"a840a9e\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-a840a9e-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-a840a9e-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-a488b62\" data-block-id=\"a488b62\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-0aa28db\" id=\"publications\" data-block-id=\"0aa28db\"><h4 class=\"stk-block-heading__text\">Publications<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-c70cfca\" data-block-id=\"c70cfca\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-c70cfca\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-c-70-cfca-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-c-70-cfca-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-7e9f2a9 stk-block-accordion__content\" data-v=\"4\" data-block-id=\"7e9f2a9\"><style>.stk-7e9f2a9-container{padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-7e9f2a9-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-7e9f2a9-inner-blocks\">\n<p>Bochynek M., et al. 2023 <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s13399-023-03821-w\" target=\"_blank\" rel=\"noreferrer noopener\">&#8220;Centrifugal partition chromatography as a potential method of isolation and purification of amphiphilic substances from a solid-state fermentation process&#8221;<\/a>. Biomass Conv. Bioref. 13:16333.<\/p>\n\n\n\n<p>Bochynek M., et al. 2023 <a href=\"https:\/\/www.frontiersin.org\/journals\/bioengineering-and-biotechnology\/articles\/10.3389\/fbioe.2023.1211319\/full\" target=\"_blank\" rel=\"noreferrer noopener\">&#8220;Formation and structural features of micelles formed by surfactin homologues&#8221;<\/a>. Front. Bioeng. Biotechnol. 11:1211319.<\/p>\n\n\n\n<p>W\u00f3jtowicz K., et al. 2021 <a href=\"https:\/\/doi.org\/10.1016\/j.bbamem.2021.183730\" target=\"_blank\" rel=\"noreferrer noopener\">&#8220;Surfactin cyclic lipopeptides change the plasma membrane composition and lateral organization in mammalian cells&#8221;<\/a>. Biochimica et Biophysica Acta, 1863:183730.<\/p>\n\n\n\n<p>Biniarz P., Henkel M., Hausmann R., \u0141ukaszewicz M. 2020 <a href=\"https:\/\/doi.org\/10.3389\/fbioe.2020.565619\" target=\"_blank\" rel=\"noreferrer noopener\">&#8220;Development of a Bioprocess for the Production of Cyclic Lipopeptides Pseudofactins With Efficient Purification From Collected Foam&#8221;<\/a>. Front Bioeng Biotechnol 8: 565619.<\/p>\n\n\n\n<p>Biniarz P., \u0141ukaszewicz M., Janek T. 2017 <a href=\"https:\/\/doi.org\/10.3109\/07388551.2016.1163324\" target=\"_blank\" rel=\"noreferrer noopener\">&#8220;Screening concepts, characterization and structural analysis of microbial-derived bioactive lipopeptides: a review&#8221;<\/a>. Crit Rev Biotechnol 37(3):393\u2013410.<\/p>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-2fdc06f is-style-plain\" data-block-id=\"2fdc06f\"><style>.stk-2fdc06f {border-style:solid !important;border-color:#dfdad1 !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:1px !important;border-left-width:0px !important;padding-bottom:24px !important;}<\/style>\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-b39e3e1 stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"b39e3e1\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-b39e3e1-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-b39e3e1-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-19fd58f\" data-block-id=\"19fd58f\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-f5047df\" id=\"example-thesis-topics\" data-block-id=\"f5047df\"><h4 class=\"stk-block-heading__text\">Example thesis topics<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-e08f3ab\" data-block-id=\"e08f3ab\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-e08f3ab\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-e-08-f-3-ab-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-e-08-f-3-ab-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-3d92b1b stk-block-accordion__content\" data-v=\"4\" data-block-id=\"3d92b1b\"><style>.stk-3d92b1b-container{padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-3d92b1b-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-3d92b1b-inner-blocks\">\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-ef12a9f\" data-block-id=\"ef12a9f\"><p class=\"stk-block-text__text\">Isolation, identification, and characterization of the biomedical properties of biosurfactants \u2013 PhD dissertation.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n<h3 class=\"wp-block-heading\"><span style=\"color: #35ae82;\" class=\"stk-highlight\">Biogas and Methanogenesis<\/span><\/h3>\n\n\n\n<p>The development of renewable energy sources is an urgent need of modern civilization. One such source is biogas, which is produced through the biological decomposition of organic matter under anaerobic conditions. The process of biogas production is complex and requires the cooperation of multiple microbial species. The Department of Biotransformation has a research facility for conducting methane fermentation under laboratory conditions, as well as equipment for basic analysis of raw materials used in biogas production.<\/p>\n\n\n\n<p>Archaea play a crucial role in methane formation, which constitutes approximately 50% of biogas. These microorganisms are at the end of the anaerobic food chain and are essential for its stable functioning. Despite their significant role in anaerobic ecosystems, only about 170 species of archaea have been isolated to date, and many aspects of their function remain unexplored. However, available data indicate that the family of methanogenic archaea is highly diverse in terms of morphological structure, metabolic capabilities, and preferred environmental conditions.<\/p>\n\n\n\n<p>The Department of Biotransformation has developed an online database (PhyMet 2) containing detailed descriptions of classified methanogenic archaea. This database serves as a valuable tool for collecting and analyzing data on microorganisms with potential industrial applications. One feature of archaea with possible industrial significance is the presence of extracellular structures known as archaella. In some species, such as <em>Methanospirillum hungatei<\/em>, archaella are responsible for active cell movement. Interestingly, genes encoding archaella proteins are also common in species that do not exhibit motility. In these cases, a possible function of archaella may be electrical conductivity, enabling electron exchange with the environment or other microorganisms.<\/p>\n\n\n\n<p>The research on methanogenesis conducted at the Department of Biotransformation aims to enhance the industrial efficiency of biogas production and to deepen the understanding of molecular and cellular mechanisms essential for the functioning of methanogenic archaea.<\/p>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-02066b7 is-style-plain\" data-block-id=\"02066b7\"><style>.stk-02066b7 {border-style:solid !important;border-color:#dfdad1 !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:1px !important;border-left-width:0px !important;padding-bottom:24px !important;}<\/style>\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-e26a67c stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"e26a67c\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-e26a67c-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-e26a67c-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-eb66276\" data-block-id=\"eb66276\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-dfa81e5\" id=\"publications\" data-block-id=\"dfa81e5\"><h4 class=\"stk-block-heading__text\">Publications<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-12b2028\" data-block-id=\"12b2028\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-12b2028\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-12-b-2028-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-12-b-2028-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-949d1d3 stk-block-accordion__content\" data-v=\"4\" data-block-id=\"949d1d3\"><style>.stk-949d1d3-container{padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-949d1d3-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-949d1d3-inner-blocks\">\n<p>Meserszmit M., et al. 2024 <a href=\"https:\/\/doi.org\/10.1016\/j.jenvman.2024.122132\" target=\"_blank\" rel=\"noreferrer noopener\">&#8220;Effect of mowing versus abandonment of mesic grasslands in Central Europe on biomass use for biogas production: Implications for semi-natural ecosystem conservation&#8221;<\/a>. J Environ Manage 368:122132.<\/p>\n\n\n\n<p>Burdukiewicz M., et al. 2018 <a href=\"https:\/\/doi.org\/10.1111\/1758-2229.12648\" target=\"_blank\" rel=\"noreferrer noopener\">&#8220;PhyMet 2\u202f: a database and toolkit for phylogenetic and metabolic analyses of methanogens&#8221;<\/a>. Environ Microbiol Rep 10(3):378\u201382.<\/p>\n\n\n\n<p>Gaworski M., et al. 2017 &#8220;<a href=\"https:\/\/doi.org\/10.1186\/s13068-017-0922-x\" target=\"_blank\" rel=\"noreferrer noopener\">Enhancing biogas plant production using pig manure and corn silage by adding wheat straw processed with liquid hot water and steam explosion&#8221;<\/a>. Biotechnology for Biofuels 10:259<\/p>\n\n\n\n<p>Jab\u0142o\u0144ski S., et al. 2015 <a href=\"https:\/\/doi.org\/10.1016\/j.wasman.2014.09.011\" target=\"_blank\" rel=\"noreferrer noopener\">&#8220;Continuous mesophilic anaerobic digestion of manure and rape oilcake \u2013 Experimental and modelling study&#8221;<\/a>. Waste Management 35:105<\/p>\n\n\n\n<p>Jab\u0142o\u0144ski S., et al. 2014 <a href=\"https:\/\/doi.org\/10.1016\/j.biortech.2014.09.151\" target=\"_blank\" rel=\"noreferrer noopener\">&#8220;Mathematical modelling of methanogenic reactor start-up: Importance of volatile fatty acids degrading population&#8221;<\/a>. Bioresource technology 174:74<\/p>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-999da5b is-style-plain\" data-block-id=\"999da5b\"><style>.stk-999da5b {border-style:solid !important;border-color:#dfdad1 !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:1px !important;border-left-width:0px !important;padding-bottom:24px !important;}<\/style>\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-1686a2e stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"1686a2e\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-1686a2e-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-1686a2e-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-07beab1\" data-block-id=\"07beab1\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-5df883d\" id=\"example-thesis-topics\" data-block-id=\"5df883d\"><h4 class=\"stk-block-heading__text\">Example thesis topics<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-6ffe9f2\" data-block-id=\"6ffe9f2\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-6ffe9f2\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-6-ffe-9-f-2-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-6-ffe-9-f-2-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0fc1b11 stk-block-accordion__content\" data-v=\"4\" data-block-id=\"0fc1b11\"><style>.stk-0fc1b11-container{padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0fc1b11-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0fc1b11-inner-blocks\">\n<p>Modelling of Anaerobic Digestion with ADM1 \u2013 PhD Dissertation by S\u0142awomir Jab\u0142o\u0144ski<\/p>\n\n\n\n<p>Identification of Methanogenic Archaea Potentially Capable of Extracellular Enzyme-Dependent Electron Uptake \u2013 Master&#8217;s Thesis<\/p>\n\n\n\n<p>Analysis of Soluble Sugar Content and Biogas Production Potential in the Biomass of Selected Grass Species \u2013 Bachelor&#8217;s Thesis<\/p>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n<h3 class=\"wp-block-heading\"><span style=\"color: #35ae82;\" class=\"stk-highlight\"><em>Saccharomyces cerevisiae<\/em> in Metabolomic Research<\/span><\/h3>\n\n\n\n<p>Yeasts of the <em>Saccharomyces<\/em> genus are a group of organisms important from both an industrial and scientific perspective. <em>Saccharomyces cerevisiae<\/em> are widely used in industry due to their ability to perform alcoholic fermentation. They produce alcohol for both food and technical purposes. Additionally, they serve as a source of various products, including higher alcohols (e.g. isobutanol), biomass used as animal feed, yeast extract, and prebiotic components such as \u03b2-glucan. <em>S.&nbsp;cerevisiae<\/em> is also one of the most commonly used organisms for heterologous protein production. Research is ongoing to develop specialized strains for specific applications, such as the fermentation of lignocellulosic biomass.<\/p>\n\n\n\n<p><em>S. cerevisiae<\/em> is a key model eukaryotic organism. Despite extensive research focused on this microorganism, many aspects of its biology remain unexplored. The function of approximately 10% of <em>S. cerevisiae<\/em> genes has yet to be determined, and its metabolic map still contains numerous gaps.<\/p>\n\n\n\n<p>At the Department of Biotransformation, we conduct research aimed at developing technologies for the production of valuable compounds using yeast or their biomass, as well as expanding knowledge on the metabolism of <em>S. cerevisiae<\/em>. Our focus is particularly on the production of volatile aromatic compounds and the metabolism of hydrophobic amino acids. Our experiments are based on a collection of yeast strains originating from natural environments and those obtained through UV-induced mutagenesis.<\/p>\n\n\n\n<p>In our research, we utilize \u00b9H-NMR techniques in collaboration with specialists from Wroc\u0142aw University of Science and Technology and GC\/MS chromatography in cooperation with Wroc\u0142aw University of Environmental and Life Sciences.<\/p>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-5cb663d is-style-plain\" data-block-id=\"5cb663d\"><style>.stk-5cb663d {border-style:solid !important;border-color:#dfdad1 !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:1px !important;border-left-width:0px !important;padding-bottom:24px !important;}<\/style>\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-e04dbef stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"e04dbef\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-e04dbef-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-e04dbef-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-31c1f94\" data-block-id=\"31c1f94\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-06ff406\" id=\"publications\" data-block-id=\"06ff406\"><h4 class=\"stk-block-heading__text\">Publications<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-566d5af\" data-block-id=\"566d5af\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-566d5af\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-566-d-5-af-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-566-d-5-af-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-41127b7 stk-block-accordion__content\" data-v=\"4\" data-block-id=\"41127b7\"><style>.stk-41127b7-container{padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-41127b7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-41127b7-inner-blocks\">\n<p>Jab\u0142o\u0144ski S.J., Mielko-Nizia\u0142ek K.A., Leszczy\u0144ski P., Gasi\u0144ski A., Kawa-Rygielska J., M\u0142ynarz P., et al. 2024 &#8220;<a href=\"https:\/\/doi.org\/10.1038\/s41598-024-64899-4\" target=\"_blank\" rel=\"noreferrer noopener\">Examination of internal metabolome and VOCs profile of brewery yeast and their mutants producing beer with improved aroma<\/a>&#8220;. Sci Rep 14(1):14582.<\/p>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-45907f5\" data-block-id=\"45907f5\"><p class=\"stk-block-text__text\">\u0141ukaszewicz M., Leszczy\u0144ski P., Jab\u0142o\u0144ski S.J., Kawa-Rygielska J. 2024 &#8220;<a href=\"https:\/\/doi.org\/10.3390\/app14062529\" target=\"_blank\" rel=\"noreferrer noopener\">Potential applications of yeast biomass derived from small-scale breweries<\/a>&#8221; Applied Sciences 14(6):2529.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n<details class=\"wp-block-stackable-accordion stk-block-accordion stk-inner-blocks stk-block-content stk-block stk-31d700e is-style-plain\" data-block-id=\"31d700e\"><style>.stk-31d700e {border-style:solid !important;border-color:#dfdad1 !important;border-top-width:0px !important;border-right-width:0px !important;border-bottom-width:1px !important;border-left-width:0px !important;padding-bottom:24px !important;}<\/style>\n<summary class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-a5c9456 stk--container-small stk-block-accordion__heading\" data-v=\"4\" data-block-id=\"a5c9456\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-a5c9456-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-a5c9456-inner-blocks\">\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-3f537fd\" data-block-id=\"3f537fd\"><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-fdf8ef6\" id=\"example-thesis-topics\" data-block-id=\"fdf8ef6\"><h4 class=\"stk-block-heading__text\">Example thesis topics<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-fd8c12d\" data-block-id=\"fd8c12d\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-fd8c12d\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-fd-8-c-12-d-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-fd-8-c-12-d-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg data-prefix=\"fas\" data-icon=\"chevron-down\" class=\"svg-inline--fa fa-chevron-down fa-w-14\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path fill=\"currentColor\" d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div><\/span><\/div>\n<\/div><\/div>\n<\/div><\/div><\/summary>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-c8b7cce stk-block-accordion__content\" data-v=\"4\" data-block-id=\"c8b7cce\"><style>.stk-c8b7cce-container{padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-c8b7cce-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-c8b7cce-inner-blocks\">\n<p>Selection of Yeast Strains with Enhanced Aromatic Ester Production for the Brewing Industry \u2013 Master&#8217;s Thesis<\/p>\n\n\n\n<p>Characterization of Selected <em>Saccharomyces cerevisiae<\/em> Strains for Industrial Applications \u2013 Master&#8217;s Thesis<\/p>\n<\/div><\/div><\/div>\n<\/details>\n\n\n<div class=\"bs__links\">\r\n    <div class=\"bs__links__section\">\r\n        <ul class=\"bs__links__list\">\r\n                            <li class=\"bs__links__list__item\">\r\n                    <a href=\"https:\/\/scholar.google.com\/citations?hl=pl&#038;user=EgHO0icAAAAJ&#038;view_op=list_works&#038;sortby=pubdate\" class=\"bs__links__list__item__link\">\r\n                        Publication Profile of Prof. Marcin \u0141ukaszewicz \r\n                        <div class=\"bs__links__list__item__link__before__icon\">\r\n                            <div class=\"bs__links__list__item__link__icon\">\r\n                                <svg width=\"40px\" height=\"40px\" viewBox=\"0 0 22 16\" version=\"1.1\">\r\n                                <g stroke=\"none\" strokeWidth=\"1\" fill=\"black\" fillRule=\"evenodd\">\r\n                                    <g>\r\n                                    <polygon points=\"13.4875 0 12 1.6215 18.7875 8 12 14.3795 13.4875 16 21.9995 8\" \/>\r\n                                    <\/g>\r\n                                <\/g>\r\n                                <\/svg>\r\n                            <\/div>\r\n                        <\/div>\r\n                    <\/a>\r\n                <li>\r\n                            <li class=\"bs__links__list__item\">\r\n                    <a href=\"https:\/\/scholar.google.com\/citations?hl=pl&#038;user=GAV3t90AAAAJ&#038;view_op=list_works&#038;sortby=pubdate\" class=\"bs__links__list__item__link\">\r\n                        Publication Profile of Dr S\u0142awomir Jab\u0142o\u0144ski \r\n                        <div class=\"bs__links__list__item__link__before__icon\">\r\n                            <div class=\"bs__links__list__item__link__icon\">\r\n                                <svg width=\"40px\" height=\"40px\" viewBox=\"0 0 22 16\" version=\"1.1\">\r\n                                <g stroke=\"none\" strokeWidth=\"1\" fill=\"black\" fillRule=\"evenodd\">\r\n                                    <g>\r\n                                    <polygon points=\"13.4875 0 12 1.6215 18.7875 8 12 14.3795 13.4875 16 21.9995 8\" 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DOROTA DZIADKOWIEC RESEARCH TEAM The role of homologous recombination mediators in DNA replication and repair and maintaining genome integrity&nbsp;in Schizosaccharomyces pombe and Saccharomyces cerevisiae. [&hellip;]<\/p>\n","protected":false},"author":20,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[],"tags":[],"class_list":["post-36034","page","type-page","status-publish","hentry"],"featured_image_urls_v2":{"full":"","thumbnail":"","medium":"","medium_large":"","large":"","1536x1536":"","2048x2048":"","menu-24x24":"","menu-36x36":"","menu-48x48":""},"post_excerpt_stackable_v2":"<p>fot. Magdalena Marcula Department of Biotransformation DEPARTMENT HEAD Dr hab. Dorota Dziadkowiec STAFF MEMBERS Prof. dr hab. Marcin \u0141ukaszewicz Dr hab. Anna Krasowska, prof. UWr Dr S\u0142awomir Jab\u0142o\u0144ski Dr Daria Derkacz Mgr B\u0142a\u017cej Przystajko PhD Students mgr Micha\u0142 Bochynek | room: 2.21, Tel: +48 71375 7062&nbsp; mgr Dorota Misiorna | room: 2.21, Tel: +48 71375 7062&nbsp; mgr Liliana Cebula | room: 2.23, Tel: +48 71375 7976 CONTACT Head: dr hab. Dorota Dziadkowiec | room: 2.20, Tel: +48 71375 6238 prof. dr hab. in\u017c. Marcin \u0141ukaszewicz | room: 2.19, Tel: +48 71375 6250&nbsp; dr hab. Anna Krasowska | room:&nbsp;2.18, Tel:&nbsp;+48 71375&hellip;<\/p>\n","category_list_v2":"Uncategorized","author_info_v2":{"name":"mmatlinski","url":"https:\/\/biotech.uwr.edu.pl\/en\/author\/mmatlinski\/"},"comments_num_v2":"0 comments","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Department of Biotransformation - Wydzia\u0142 Biotechnologii<\/title>\n<meta name=\"description\" content=\"Wydzia\u0142 Biotechnologii\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biotech.uwr.edu.pl\/en\/department-of-biotransformation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Department of Biotransformation - Wydzia\u0142 Biotechnologii\" \/>\n<meta property=\"og:description\" content=\"Wydzia\u0142 Biotechnologii\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biotech.uwr.edu.pl\/en\/department-of-biotransformation\/\" \/>\n<meta property=\"og:site_name\" content=\"Wydzia\u0142 Biotechnologii\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-27T13:24:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1600\" \/>\n\t<meta property=\"og:image:height\" content=\"1067\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"20 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biotech.uwr.edu.pl\/en\/department-of-biotransformation\/\",\"url\":\"https:\/\/biotech.uwr.edu.pl\/en\/department-of-biotransformation\/\",\"name\":\"Department of Biotransformation - 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