{"id":35902,"date":"2022-06-25T13:01:13","date_gmt":"2022-06-25T11:01:13","guid":{"rendered":"https:\/\/biotech.uwr.edu.pl\/zaklad-patologii-komorki\/"},"modified":"2025-11-27T14:32:53","modified_gmt":"2025-11-27T13:32:53","slug":"department-of-cell-pathology","status":"publish","type":"page","link":"https:\/\/biotech.uwr.edu.pl\/en\/department-of-cell-pathology\/","title":{"rendered":"Department of Cell Pathology"},"content":{"rendered":"\n<div class=\"wp-block-ugb-container ugb-container blok_nowa_podstrona ugb-8dda971 ugb-container--v2 ugb-container--design-plain ugb-main-block\"><div class=\"ugb-inner-block\"><div class=\"ugb-block-content\"><div class=\"ugb-container__wrapper ugb-8dda971-wrapper\"><div class=\"ugb-container__side\"><div class=\"ugb-container__content-wrapper ugb-8dda971-content-wrapper\">\n<div class=\"wp-block-columns bs-news-page is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column bs-kontakt-photo is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1024x683.jpg\" alt=\".\" class=\"wp-image-34812\" srcset=\"https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1024x683.jpg 1024w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-300x200.jpg 300w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-768x512.jpg 768w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1536x1024.jpg 1536w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-1320x880.jpg 1320w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-24x16.jpg 24w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-36x24.jpg 36w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6-48x32.jpg 48w, https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6.jpg 1600w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">fot. Magdalena Marcula<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column bs-contact-right-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-bonasoft-modular-breadcrumbs-block\"><div class=\"bs_add_breadcrumb_trail\"><\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-black-color has-css-opacity has-black-background-color has-background is-style-wide bs-border-kontakt\"\/>\n\n\n\n<h1 class=\"wp-block-heading bs-naglowek-podstrony\">Department of Cell Pathology<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>HEAD OF THE LABORATORY<\/strong><\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"color: var(--ast-global-color-8)\" class=\"stk-highlight\"><a href=\"https:\/\/old.uni.wroc.pl\/en\/search-for-employees\/employee\/?p_id=595143\">Prof. dr hab. Dorota Nowak<\/a><\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">STAFF<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/old.uni.wroc.pl\/en\/search-for-employees\/employee\/?p_id=597325\" target=\"_blank\" rel=\"noreferrer noopener\">Dr hab. Antonina Mazur, prof. UWr<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/old.uni.wroc.pl\/en\/search-for-employees\/employee\/?p_id=594482\" target=\"_blank\" rel=\"noreferrer noopener\">Mgr Ilona Stycze\u0144<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/old.uni.wroc.pl\/en\/search-for-employees\/employee\/?p_id=599034\" target=\"_blank\" rel=\"noreferrer noopener\">Dr Aleksandra Simiczyjew<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/old.uni.wroc.pl\/en\/search-for-employees\/employee\/?p_id=691526\" target=\"_blank\" rel=\"noreferrer noopener\">Dr Katarzyna Pietraszek-Gremplewicz<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-ugb-container ugb-container bs-news-page-under ugb-f8694ce ugb-container--v2 ugb-container--design-plain ugb-main-block\"><div class=\"ugb-inner-block\"><div class=\"ugb-block-content\"><div class=\"ugb-container__wrapper ugb-f8694ce-wrapper\"><div class=\"ugb-container__side\"><div class=\"ugb-container__content-wrapper ugb-f8694ce-content-wrapper\">\n<h2 class=\"wp-block-heading\"><strong>RESEARCH TOPICS AND THE MOST IMPORTANT RESULTS<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Nowak Team<\/li>\n<\/ul>\n\n\n\n<p>In our projects, we focus on the aspects of tumor progression important for metastasis formation and which may affect the development of more effective anticancer therapies. Using melanoma, triple-negative breast cancer, and colon cancer cell lines, as well as cells isolated from melanoma patients, we endeavor to study the invasiveness and tumor microenvironment of these cells.<\/p>\n\n\n\n<p>We have shown&nbsp;<em>in vitro<\/em>&nbsp;efficiency of combination therapy using inhibitors of EGFR and MET receptors, and characterized the phenotype of resistant melanoma cells. Moreover, we have demonstrated that the regulation of colon cancer cell invasiveness is dependent on the level of apelin, an adipokine associated a.o. with obesity and heart diseases. In addition, we also aim to fully uncover the role of adipokines secreted by adipose tissue&nbsp;<em>in vivo<\/em>&nbsp;and adipocytes in vitro on different stages of melanoma and colon cancer progression.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Mazur Team<\/li>\n<\/ul>\n\n\n\n<p>Our goal is to discover the differences in functions of proteins important for cell motility between embryonic and melanoma cells. Melanoma stems from pigment cells, which originate from neural crest cells, which similarly to melanoma cells are characterized by high migratory potential.<\/p>\n\n\n\n<p>We have shown that gelsolin is important for melanoma cell migration on laminin, a protein present in the extracellular matrix and essential for the development of neural crest cell derivatives. In addition, we have demonstrated that the recently discovered actin isoform (actbl2) is important for melanoma cell motility.<\/p>\n\n\n\n<p>To realize our goals, we have created a unique laboratory to conduct experiments on chicken embryos.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>COLLABORATIONS<\/strong><\/h2>\n\n\n\n<p>We collaborate with dr. hab. \u0141ukasz John and dr. hab. Anna Skar\u017cy\u0144ska (Faculty of Chemistry UWr), dr. hab. Piotr Donizy and dr. Piotr Kupczyk (Wroclaw Medical University), as well as prof. Rafa\u0142 Matkowski and&nbsp; dr. Marcin Zi\u0119tek (Lower Silesian Oncology Center).<\/p>\n\n\n\n<p>In addition to national research institutes, we also work closely with prof. Hans Mannherz (Ruhr University Bochum, Germany), prof. Staffan Str\u00f6mblad (Karolinska Institutet, Sweden), prof. Marco Lazzarino (IOMN Research Council, Italy), prof. Christophe Ampe (Universiteit Gent, Belgium), and prof. Stephane Brezillon (Universit\u00e9 de Reims Champagne-Ardenne, France).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>EXAMPLE DOCTORAL DISSERTATION TOPICS<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u201cThe role of adipocytes in the colon cancer invasiveness\u201d, Joanna Olsza\u0144ska.<\/li>\n\n\n\n<li>\u201cDetermination of the role of extracellular integrin-dependent kinase (ILK) in adhesion, migration \/ invasion and proliferation of melanoma cells\u201d, Agata G\u00f3rska.<\/li>\n\n\n\n<li>\u201cThe effect of tumor microenvironment on efficiency of melanoma targeted therapy\u201d, Justyna Mazurkiewicz.<\/li>\n\n\n\n<li>\u201cEffect of gelsolin, non-integrin laminin receptor and integrin-dependent kinase on the development of the peripheral nervous system of a chicken embryo\u201d, Ewa Mr\u00f3wczy\u0144ska.<\/li>\n\n\n\n<li>\u201cThe role of selected gelsolin isoforms in the migration of human melanoma cells, and their influence on the localization of the non-integrin laminin receptor in the cell\u201d, Ewa Mazurkiewicz.<\/li>\n\n\n\n<li>\u201cRole of apelin and its receptor in the progression of colon cancer\u201d, Marta Podg\u00f3rska, 2021.<\/li>\n\n\n\n<li>\u201cEGFR and c-Met inhibitors as factors limiting the invasiveness of human melanoma cells\u201d, Ewelina Dratkiewicz, 2020.<\/li>\n\n\n\n<li>\u201cThe effect of gelsolin and thymosin \u03b24 on ithe invasiveness of melanoma cells\u201d, Aleksandra Makowiecka, 2019.<\/li>\n\n\n\n<li>\u201cFunctional diversification of actin isoforms in the process of cell migration\u201d, Aleksandra Simiczyjew, 2015.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>CURRENT BACHELOR\u2019S AND MASTER\u2019S THESES<\/strong><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">Bachelor&#8217;s<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u201cThe role of structural components of extracellular matrix proteins in melanoma progression\u201d<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Master&#8217;s<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u201cCharacterization of Hs294T cells with impaired expression of a gene coding for gelsolin\u201d<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>RESEARCH PROJECTS<\/strong><\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Current<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>NCN SONATA 16: \u201eChanges in lipid metabolism of resistant to BRAF\/MEK inhibitors human melanoma cells associated with the presence of adipocytes within tumor niche\u201d, (2021-2024).<\/li>\n\n\n\n<li>Head of the project: dr Aleksandra Simiczyjew.<\/li>\n\n\n\n<li>NCN PRELUDIUM 19: \u201eDetermination of the mechanisms responsible for the impact of non-integrin laminin receptor (LamR) on the developmenDetermination of the mechanisms responsible for the mobility of non-integrin laminin receptor (LamR) isoforms, including unstudied yet LamR long isoform, in the plasma membrane of human melanoma cells\u201d, (2021-2023).<\/li>\n\n\n\n<li>Head of the project: mgr Ewa Mazurkiewicz.<\/li>\n\n\n\n<li>NCN PRELUDIUM 19: \u201eDetermination of the mechanisms responsible for the impact of non-integrin laminin receptor (LamR) on the development of neurites and Schwann cell precursors at the stage of dorsal root ganglia (DRG) development\u201d, (2021-2023).<\/li>\n\n\n\n<li>Head of the project: mgr Ewa Mr\u00f3wczy\u0144ska.<\/li>\n\n\n\n<li>NCN PRELUDIUM BIS 1: \u201eDetermination of the role of present in extracelluar space integrin-linked kinase (ILK) in adhesion, migration\/invasion and proliferation of melanoma cells\u201d, (2020-2024).<\/li>\n\n\n\n<li>Head of the project: dr hab. Antonina Mazur.<\/li>\n\n\n\n<li>NCN OPUS 15: \u201eThe effect of tumor microenvironment on efficiency of melanoma targeted therapy\u201d, (2019-2022).<\/li>\n\n\n\n<li>Head of the project: dr hab. Dorota Nowak.<\/li>\n\n\n\n<li>NCN SONATA BIS 6: \u201eThe role of gelsolin and its complexes with LamR and ILK in adhesion to laminin and migration\/invasion of normal and tumor cells\u201d, (2017-2022).<\/li>\n\n\n\n<li>Head of the project: dr Antonina Mazur.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Accomplished<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Polish-French Partnership Programme POLONIUM: \u201eThe influence of lumican and its peptide derivatives on the formation and activity of invadopodia in a variety of human tumor cell lines\u201d, (2017-2018).<\/li>\n\n\n\n<li>Head of the project: dr hab. Dorota Nowak, prof. Stephane Brezillon.<\/li>\n\n\n\n<li>NCN ETIUDA 5: \u201eThe effect of gelsolin and thymosin \u03b24 on ithe invasiveness of melanoma cells\u201d, (2017-2018).<\/li>\n\n\n\n<li>Head of the project: mgr Aleksandra Makowiecka.<\/li>\n\n\n\n<li>NCN SONATA 12: \u201eRole of apelin and its receptor in the progression of colon cancer\u201d, (2017-2021).<\/li>\n\n\n\n<li>Head of the project: dr Katarzyna Pietraszek-Gremplewicz.<\/li>\n\n\n\n<li>NCN OPUS 9: \u201eCharacterization of actbl2 \u2013 recently discovered actin isoform and its role in migration and invasion of human melanoma cells\u201d, (2016-2020).<\/li>\n\n\n\n<li>Head of the project: dr Antonina Mazur.<\/li>\n\n\n\n<li>NCN OPUS 8: \u201eEGFR and c-Met inhibitors as factors limiting the invadopodia formation in human melanoma cells\u201d, (2015-2018).<\/li>\n\n\n\n<li>Head of the project: dr hab. Dorota Nowak<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>LABORATORY EQUIPMENT<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Fully equipped mammalian and bacterial cell culture room with:<\/li>\n<\/ul>\n\n\n\n<p>\u00b7 a hypoxia incubator;<br>\u00b7 an incubator for insect cell culture;<br>\u00b7 fluorescence inverted microscope Leica DMI3000 B<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Confocal fluorescence microscope FluoView 500 (Olympus)<\/li>\n\n\n\n<li>Gel imaging and analysis system ChemiDoc (Bio-Rad)<\/li>\n\n\n\n<li>Microplate spectrophotometer \u00b5Quant (BioTek Instruments)<\/li>\n\n\n\n<li>Fully equipped laboratory for chicken embryo experiments:<\/li>\n<\/ul>\n\n\n\n<p>\u00b7 Hybridization oven Hybaid\u2019n\u2019Stack (ThermoFisher);<br>\u00b7 TSS20 Ovodyne Electroporator (Intracel);<br>\u00b7 McIlwain Tissue Chopper (Ted Pella, Inc.);<br>\u00b7 Leica M205 fluorescence stereo microscope;<br>\u00b7 Zeiss Stemi 305 microscope;<br>\u00b7 chicken egg incubator<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">PUBLICATIONS<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Mr\u00f3wczy\u0144ska E., Mazur A.J. Integrin-Linked Kinase (ILK) Plays an Important Role in the Laminin-Dependent Development of Dorsal Root Ganglia during Chicken Embryogenesis.&nbsp;<em>Cells<\/em>. 2021 Jul 2;10(7):1666<\/li>\n\n\n\n<li>Erdmann C., Hassoun R., Schmitt S., Kikuti C., Houdusse A., Mazur A.J., M\u00fcggeA., Hamdani N., Geyer M., Jaquet K., Mannherz H.G. (2021) Integration of Cardiac Actin Mutants Causing Hypertrophic (p.A295S) and Dilated Cardiomyopathy (p.R312H and p.E361G) into Cellular Structures.&nbsp;<em>Antioxidants (Basel).&nbsp;<\/em>2021 5;10(7):1082<\/li>\n\n\n\n<li>Makowiecka A., Mazurkiewicz E., Mr\u00f3wczy\u0144ska E., Malek N., Battistella A., Lazzarino M., Nowak D., Mazur A. J. (2021) Changes in Biomechanical Properties of A375 Cells Due to the Silencing of TMSB4X Expression Are Not Directly Correlated with Alterations in Their Stemness Features.&nbsp;<em>Cells<\/em>. 2021 Mar 31;10(4):769<\/li>\n\n\n\n<li>Dratkiewicz E., Simiczyjew A., Mazurkiewicz J., Zi\u0119tek M., Matkowski R., Nowak D. (2021) Hypoxia and Extracellular Acidification as Drivers of Melanoma Progression and Drug Resistance.&nbsp;<em>Cells.<\/em>&nbsp;2021, 10(4), 862<\/li>\n\n\n\n<li>Mazurkiewicz E., Mr\u00f3wczy\u0144ska E., Simiczyjew A., Nowak D., Mazur A. J. (2021) A Fluorescent Gelatin Degradation Assay to Study Melanoma Breakdown of Extracellular Matrix.&nbsp;<em>Methods Mol Biol<\/em>. 2021;2265:47-63<\/li>\n\n\n\n<li>Malek N., Michrowska A., Mazurkiewicz E., Mr\u00f3wczy\u0144ska E., Mackiewicz P., Mazur A. J. (2021) The origin of the expressed retrotransposed gene ACTBL2 and its influence on human melanoma cells\u2019 motility and focal adhesion formation.&nbsp;<em>Sci Rep<\/em>. 2021 Feb 8;11(1):3329<\/li>\n\n\n\n<li>Kupczyk P., Simiczyjew A., Marczuk J., Dratkiewicz E., Beberok A., Rok J., Pieniazek M., Biecek P., Nevozhay D., Slowikowski B., Chodaczek G., Wrzesniok D., Nowak D., Donizy P. (2021) PARP1 as a Marker of an Aggressive Clinical Phenotype in Cutaneous Melanoma-A Clinical and an In Vitro Study.&nbsp;<em>Cells<\/em>. 2021 Jan 31;10(2):286<\/li>\n\n\n\n<li>Podg\u00f3rska M., Pietraszek-Gremplewicz K., Olsza\u0144ska J., Nowak D. (2021) The Role of Apelin and Apelin Receptor Expression in Migration and Invasiveness of Colon Cancer Cells.&nbsp;<em>Anticancer Res.<\/em>&nbsp;Jan 2021 41 (1) 151-161<\/li>\n\n\n\n<li>Mazurkiewicz J., Simiczyjew A., Dratkiewicz E., Zi\u0119tek M., Matkowski R., Nowak D. (2021) Stromal Cells Present in the Melanoma Niche Affect Tumor Invasiveness and Its Resistance to Therapy.&nbsp;<em>Int J Mol Sci<\/em>. 2021, 22(2), 529<\/li>\n\n\n\n<li>Simiczyjew A., Dratkiewicz E., Mazurkiewicz J., Zi\u0119tek M., Matkowski R., Nowak D. (2020) The Influence of Tumor Microenvironment on Immune Escape of Melanoma.&nbsp;<em>Int J Mol Sci<\/em>. 2020 Nov 7;21(21):E8359<\/li>\n\n\n\n<li>Malek N, Mr\u00f3wczy\u0144ska E, Michrowska A, Mazurkiewicz E, Pavlyk I, Mazur AJ. (2020) Knockout of ACTB and ACTG1 With CRISPR\/Cas9(D10A) Technique Shows That Non-Muscle \u03b2 and \u03b3 Actin Are Not Equal in Relation to Human Melanoma Cells\u2019 Motility and Focal Adhesion Formation.&nbsp;<em>Int J Mol Sci<\/em>. 2020 Apr 15;21(8):2746<\/li>\n\n\n\n<li>Dratkiewicz E., Simiczyjew A., Pietraszek-Gremplewicz K., Mazurkiewicz J., Nowak D. (2019) Characterization of Melanoma Cell Lines Resistant to Vemurafenib and Evaluation of Their Responsiveness to EGFR- and MET-Inhibitor Treatment.&nbsp;<em>Int J Mol Sci<\/em>. 2019 Dec 23;21(1)<\/li>\n\n\n\n<li>Pietraszek-Gremplewicz K., Simiczyjew A., Dratkiewicz E., Podg\u00f3rska M., Stycze\u0144 I., Matkowski R., Zi\u0119tek M., Nowak D. (2019) Expression level of EGFR and MET receptors regulates invasiveness of melanoma cells.&nbsp;<em>J Cell Mol Med<\/em>. 2019 Dec;23(12):8453-8463<\/li>\n\n\n\n<li>Makowiecka A., Malek N., Mazurkiewicz E., Mr\u00f3wczy\u0144ska E., Nowak D., Mazur AJ. (2019) Thymosin \u03b24 Regulates Focal Adhesion Formation in Human Melanoma Cells and Affects Their Migration and Invasion.&nbsp;<em>Front Cell Dev Biol<\/em>. 2019 Dec 23;7:304<\/li>\n\n\n\n<li>Simiczyjew A., Pietraszek-Gremplewicz K., Dratkiewicz E., Podg\u00f3rska M., Matkowski R., Zi\u0119tek M., Nowak D. (2019) Combination of Selected MET and EGFR Inhibitors Decreases Melanoma Cells\u2019 Invasive Abilities.&nbsp;<em>Front Pharmacol<\/em>. 2019 Oct 1;10:1116<\/li>\n\n\n\n<li>Podg\u00f3rska M., Diakowska D., Pietraszek-Gremplewicz K., Nienartowicz M., Nowak D. (2019) Evaluation of Apelin and Apelin Receptor Level in the Primary Tumor and Serum of Colorectal Cancer Patients.&nbsp;<em>J Clin Med<\/em>. 2019 Sep 20;8(10)<\/li>\n\n\n\n<li>Simiczyjew A., Dratkiewicz E., Van Troys M., Ampe C., Stycze\u0144 I., Nowak D. (2018) Combination of EGFR Inhibitor Lapatinib and MET Inhibitor Foretinib Inhibits Migration of Triple Negative Breast Cancer Cell Lines.&nbsp;<em>Cancers (Basel);<\/em>&nbsp;2018 Sep 17;10(9).<\/li>\n\n\n\n<li>Podg\u00f3rska M., Pietraszek-Gremplewicz K., Nowak D. (2018) Apelin Effects Migration and Invasion Abilities of Colon Cancer Cells.&nbsp;<em>Cells;<\/em>&nbsp;2018 Aug 20;7(8).<\/li>\n\n\n\n<li>Wysocka M.B., Pietraszek-Gremplewicz K., Nowak D. (2018) The role of apelin in cardiovascular diseases, obesity and cancer.&nbsp;<em>Front Physiol<\/em>; 9:557<\/li>\n\n\n\n<li>Dratkiewicz E., Pietraszek-Gremplewicz K., Simiczyjew&nbsp;A., Mazur&nbsp;A.J.,&nbsp;Nowak D. (2018) Gefitinib or lapatinib with foretinib synergistically induce a cytotoxic effect in melanoma cell lines.&nbsp;<em>Oncotarget<\/em>;&nbsp;9:18254-18268.<\/li>\n\n\n\n<li>Simiczyjew A., Pietraszek-Gremplewicz K., Mazur A.J., Nowak D. (2017) Are non-muscle actin isoforms functionally equivalent?&nbsp;<em>Histol Histopathol<\/em>; 32(11):1125-1139.<\/li>\n\n\n\n<li>Simiczyjew A., Mazur A.J., Dratkiewicz E., Nowak D. (2017) Involvement of \u03b2- and \u03b3-actin isoforms in actin cytoskeleton organization and migration abilities of bleb-forming human colon cancer cells.&nbsp;<em>PLoS One<\/em>; 23;12(3).<\/li>\n\n\n\n<li>Masuzzo P., Huyck L., Simiczyjew A., Ampe C., Martens L., Van Troys M. (2017)&nbsp;An end-to-end software solution for the analysis of high-throughput single-cell migration data.&nbsp;<em>Sci Rep;&nbsp;<\/em>7:42383<\/li>\n\n\n\n<li>Makowiecka A., Simiczyjew A., Nowak D., Mazur A.J. (2016)&nbsp;Varying effects of EGF, HGF and TGF\u03b2 on formation of invadopodia and invasiveness of melanoma cell lines of different origin.&nbsp;<em>Eur J Histochem<\/em>; 60(4):2728.<\/li>\n\n\n\n<li>Baczynska D., Bombik I., Malicka-B\u0142aszkiewicz M. (2016) \u03b2-Catenin Expression Regulates Cell Migration of Human Colonic Adenocarcinoma Cells Through Gelsolin.&nbsp;<em>Anticancer Res<\/em>; 36(10):5249-5256.<\/li>\n\n\n\n<li>Mazur A.J., Radaszkiewicz T., Makowiecka A., Malicka-B\u0142aszkiewicz M., Mannherz H.G., Nowak D. (2016) Gelsolin interacts with LamR, hnRNP U, nestin, Arp3 and \u03b2-tubulin in human melanoma cells as revealed by immunoprecipitation and mass spectrometry.&nbsp;<em>Eur J Cell Biol;<\/em>&nbsp;95(1):26-41.<\/li>\n\n\n\n<li>Simiczyjew A., Mazur AJ., Ampe C., Malicka-B\u0142aszkiewicz M., van Troys M., Nowak D. (2015) Active invadopodia of mesenchymally migrating cancer cells contain both \u03b2 and \u03b3 cytoplasmic actin isoforms.&nbsp;<em>Exp Cell Res<\/em>; 339(2):206-19.<\/li>\n\n\n\n<li>Migocka-Patrza\u0142ek M., Makowiecka A., Nowak D., Mazur A.J., Hofmann W.A., Malicka-B\u0142aszkiewicz M. (2015)&nbsp;\u03b2- and \u03b3-Actins in the nucleus of human melanoma A375 cells.&nbsp;<em>Histochem Cell Biol<\/em>; 144(5):417-28.<\/li>\n\n\n\n<li>Mazur A.J., Morosan-Puopolo G., Makowiecka A., Malicka-B\u0142aszkiewicz M., Nowak D.&nbsp;<sup>&nbsp;<\/sup>and Brand-Saberi B. (2014) Analysis of gelsolin expression pattern in developing chicken embryo reveals high GSN expression level in tissues of neural crest origin.&nbsp;<em>Brain Structure &amp; Function<\/em>&nbsp;DOI: 10.1007\/s00429-014-0923-5.<\/li>\n\n\n\n<li>Al Haj, A., Mazur, A. J., Radaszkiewicz, K., Radaszkiewicz, T., Makowiecka, A., Stopschinski, B. E., Schonichen A., Geyer M. and Mannherz, H. G. (2014). Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres.&nbsp;<em>European Journal of Cell Biology;<\/em>&nbsp;1\u201313. doi:10.1016\/j.ejcb.2014.11.003<\/li>\n\n\n\n<li>Simiczyjew A., Mazur A.J., Popow-Wo\u017aniak A., Malicka-B\u0142aszkiewicz M., Nowak D. (2014) Effect of overexpression of&nbsp;\u03b2- and \u03b3-actin&nbsp; isoforms&nbsp; on actin cytoskeleton organization and migration of human colon cancer cells.&nbsp;<em>Histochem Cell Biology<\/em>; 2014 142(3):307-322.<\/li>\n\n\n\n<li>Al Haj, A., Mazur, A. J., Buchmeier, S., App, C., Theiss, C., Silvan, U., Schoenenberger C. Jousch B. M., Hannappel E., Weeds A.G and Mannherz, H. G. (2014). Thymosin beta4 inhibits ADF\/cofilin stimulated F-actin cycling and hela cell migration: Reversal by active Arp2\/3 complex.&nbsp;<em>Cytoskeleton<\/em>&nbsp;(Hoboken, N.J.); 71 Issue 2, 95-107.<\/li>\n\n\n\n<li>Che\u0142mo\u0144ska-Soyta A., Ozgo M., Lepczynski A., Herosimczyk A., Buska K., Kedzierska A., Nowak D., Mazur A. (2014) Proteome of spleen CD4 lymphocytes in mouse preimplantation pregnancy,&nbsp;<em>Journal of Physiology and Pharmacology;<\/em>&nbsp;65,5, 719-731.<\/li>\n\n\n\n<li>Simiczyjew A., Malicka-B\u0142aszkiewicz M., Nowak D. (2013) Funkcjonalne zr\u00f3\u017cnicowanie cytoplazmatycznych izoform aktyny.&nbsp;<em>Post\u0119py Biochemii;<\/em>&nbsp;59, 285-294.<\/li>\n\n\n\n<li>Schonichen A., Mannherz H.G., Behrmann E., Mazur A.J., Kuhn S., Silvan U., Schoenenberger C.A., Fackler O.T., Raunser S., Dehmelt L., Geyer M. (2013) FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibres. &nbsp;<em>Journal of Cell Science;<\/em>&nbsp;126: 1891-1901<\/li>\n\n\n\n<li>Litwin M, Nowak D, Mazur AJ,&nbsp; Baczy\u0144ska D, Mannherz HG., Malicka-Blaszkiewicz M (2012) Gelsolin affects the migratory ability of human colon adenocarcinoma and melanoma cells&nbsp;&nbsp;<em>Life Sci<\/em>&nbsp; 90, 851-61.<\/li>\n\n\n\n<li>Popow-Wo\u017aniak A, Mazur AJ, Mannherz HG., Malicka-B\u0142aszkiewicz M., Nowak D. (2012) Cofilin overexpression affects actin cytoskeleton organization and migration of human colon adenocarcinoma cells \u2013&nbsp;<em>Histochem Cell Biology;&nbsp;<\/em>138, 725-736<em>.<\/em><\/li>\n\n\n\n<li>Radwanska A, Litwin M, Nowak&nbsp; D, BaczynskaD, Wegrowski Y, Maquart FX, Malicka-B\u0142aszkiewicz M (2012) Overexpression of lumican affects the migration of human colon cancer cells through up-regulation of gelsolin and filamentous actin reorganization.&nbsp;<em>Exp Cell Res;&nbsp;<\/em>318, 2312-2323<\/li>\n\n\n\n<li>M\u00fcller M.*, Mazur A.J.*, Behrmann E., Diensthuber R.P., Radke M.B., Qu Z., Littwitz C., Raunser S., Schoenenberger C.A., Manstein D.J., Mannherz H.G. (2012) \u201e<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22643837\">Functional characterization of the human \u03b1-cardiac actin mutations Y166C and M305L involved in hypertrophic cardiomyopathy\u201d.<\/a>&nbsp;<em>Cell Mol Life Sci<\/em>., 69, 3457-79, *-both authors equally contributed to the work<\/li>\n\n\n\n<li>Bechara, F.G., Mannherz, H.G., Jacob, M., Mazur A.J., Sand, M.,&nbsp; Altmeyer, P., Hoffmann, K.(2012) \u201cInduction of fat cell necrosis in human fat tissue after treatment with phosphatidylcholine and deoxycholate.\u201d&nbsp;<em>Journal of the European Academy of Dermatology and Venereology<\/em>&nbsp;26, 180-185,<\/li>\n\n\n\n<li>Popow-Wo\u017aniak A.<sup>,<\/sup>,Wo\u017aniakowskaA.,, Kaczmarek \u0141., Malicka-B\u0142aszkiewicz M., Nowak D (2011)Apoptotic effect of imatinib on human colon adenocarcinoma cells: influence on actin cytoskeleton organization and cells migration.&nbsp;<em>Eur.J. Pharmacol<\/em>., 667, 66-73.<\/li>\n\n\n\n<li>Nowak D, Mazur A, Popow-Wo\u017aniak A., Radwa\u0144ska A.,Mannherz H.G, Malicka-B\u0142aszkiewicz M (2010)Subcellular distribution and expression of cofilin and ezrin in human colon adenocarcinoma cell lines with different metastatic potential.&nbsp;<em>Eur J Histochem,&nbsp;<\/em>54(2), 59-66.<\/li>\n\n\n\n<li>Machaidze, G., Sokoll, A., Shimada, A., Lustig, A., Mazur, A.J., Wittinghofer, A., Aebi, U., Mannherz H.G. \u201cActin Filament Bundling and Different Nucleating Effects of Mouse Diaphanous-Related Formin FH2 Domains on Actin:ADF and Actin:Cofilin Complexes\u201d.&nbsp;<em>Journal of Molecular Biology<\/em>&nbsp;403, 529-45, 2010<\/li>\n\n\n\n<li>Mannherz, H.G., Mazur, A.J., Jockusch, B. \u201cRepolymerisation of Actin from Actin:Thymosin beta 4 complex induced by diaphanous related formins and gelsolin\u201d.&nbsp;<em>Annals of the New York Academy of Sciences<\/em>&nbsp;1194, 36-43, 2010<br>Mazur, A.J., Gremm, D., Dansranjavin, T., Litwin, M., Jockusch, B.M., Wegner, A., Weeds, A.G., Mannherz, H.G.: Modulation of actin filament dynamics by actin binding proteins residing in lamellipodia.&nbsp;<em>European Journal of Cell Biology<\/em>&nbsp;89, 402-413, 2010.<\/li>\n\n\n\n<li>Litwin M., Mazur A.J, Nowak D., Mannherz H.G, Malicka-B\u0142aszkiewicz M. (2009) Gelsolin In human colon adenocarcinoma cells with different metastatic potential.&nbsp;<em>Acta Biochim. Polon<\/em>, 56(4), 739-743.<\/li>\n\n\n\n<li>Mazur A.,&nbsp;<sup>&nbsp;<\/sup>Nowak D., Mannherz H.G, Malicka-B\u0142aszkiewiczM.(2009) Apoptotic effect of methotexate on CaSki and NRK cells \u2013 influence on actin cytoskeleton organization ,&nbsp;<em>Eur.J. Pharmacol.<\/em><\/li>\n\n\n\n<li>Popow-Wo\u017aniak A, Nowak D., Malicka-B\u0142aszkiewicz M.(2009) Sposoby migracji kom\u00f3rek nowotworowych.&nbsp;<em>Post\u0119py Biochemii<\/em>, 55(2), 113-120.<\/li>\n\n\n\n<li>Nowak .D, &nbsp;Popow-Wo\u017aniak A,Ra\u017anikiewicz L., Malicka-B\u0142aszkiewicz M. (2009) Aktyna w procesie gojenia ran.&nbsp;<em>Post\u0119py Biochemii,&nbsp;<\/em>55(2), 138-144.<\/li>\n\n\n\n<li>Mannherz H.G., Mach M.,&nbsp; Mazur A., Nowak D., Malicka-B\u0142aszkiewicz M. (2008)\u2002Lamellipodial and ameboid cell locomotion: the role of actin-cycling and bleb formation.&nbsp;<em>Biophys. Rev. Lett<\/em>., 2, no 1, 1-18.<\/li>\n\n\n\n<li>Radwanska A., Baczynska D., Nowak D., Brezillon S., Popow A., Macquart F.X., Wegrowski Y, Malicka-B\u0142aszkiewicz M. (2008) Lumican affects actin cytoskeletal organization in human melanoma A375 cells.&nbsp;<em>Life Sciences<\/em>, 83, 651-660.<\/li>\n\n\n\n<li>Theiss, C., Mazur A., Meller K., Mannherz H.G. (2007) Changes in gap junction organization and decreased coupling during induced apoptosis in lens epithelial and NIH-3T3 cells.&nbsp;<em>Experimental Cell Research<\/em>&nbsp;313, 28-52.<\/li>\n\n\n\n<li>Popow A., Nowak D., Malicka-B\u0142aszkiewicz M (2006) Actin cytoskeleton and beta-actin expression in correlation with higher invassiveness of selected hepatoma Morris 5123 cells;&nbsp;<em>J. Physiol. Pharmacol<\/em>., 57, 111-124.<\/li>\n\n\n\n<li>Nowak D., Skwarek-Maruszewska A., Zemanek-Zboch M., Malicka-B\u0142aszkiewicz M. (2005) Beta actin in human colon adenocarcinoma cells with different metastatic potential.&nbsp;<em>Acta Biochim. Polon<\/em>. 52, 461-468. 1,6 IF;<\/li>\n\n\n\n<li>Osi\u0144ska-Kr\u00f3licka I., Podsiad\u0142y H., Bukiety\u0144ska K., Zemanek-Zboch M., Nowak D., Suchoszek-\u0141ukaniuk K.,&nbsp; Malicka-B\u0142aszkiewicz M. (2004) Vanadium(III) complexes with L-Cysteine \u2013 stability, speciation and the effect on actin in hepatoma Morris 5123 cells.&nbsp;<em>J. Inorg.Biochem.<\/em>, 98, 2087-2098. 3.5 IF; 32pkt<\/li>\n\n\n\n<li>Nowak D., Krawczenko A., Du\u015b D., Malicka-B\u0142aszkiewicz M.(2002) Actin in human colon adenocarcinoma cells with different metastatic potential.&nbsp;<em>Acta Biochim. Polon<\/em>. 4, 823-828.<\/li>\n\n\n\n<li>Nowak D., Malicka-B\u0142aszkiewicz M., (1999) Izoformy aktyny \u2013 zr\u00f3\u017cnicowanie funkcji, zmiany w stanach patologicznych.&nbsp;<em>Post\u0119py Biochemii<\/em>&nbsp;45 (4): 261-269.<\/li>\n<\/ol>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Department of Cell Pathology HEAD OF THE LABORATORY STAFF RESEARCH TOPICS AND THE MOST IMPORTANT RESULTS In our projects, we focus on the aspects of tumor progression important for metastasis formation and which may affect the development of more effective anticancer therapies. Using melanoma, triple-negative breast cancer, and colon cancer cell lines, as well as [&hellip;]<\/p>\n","protected":false},"author":20,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[],"tags":[],"class_list":["post-35902","page","type-page","status-publish","hentry"],"featured_image_urls_v2":{"full":"","thumbnail":"","medium":"","medium_large":"","large":"","1536x1536":"","2048x2048":"","menu-24x24":"","menu-36x36":"","menu-48x48":""},"post_excerpt_stackable_v2":"<p>fot. Magdalena Marcula Department of Cell Pathology HEAD OF THE LABORATORY Prof. dr hab. Dorota Nowak STAFF Dr hab. Antonina Mazur, prof. UWr Mgr Ilona Stycze\u0144 Dr Aleksandra Simiczyjew Dr Katarzyna Pietraszek-Gremplewicz RESEARCH TOPICS AND THE MOST IMPORTANT RESULTS Nowak Team In our projects, we focus on the aspects of tumor progression important for metastasis formation and which may affect the development of more effective anticancer therapies. Using melanoma, triple-negative breast cancer, and colon cancer cell lines, as well as cells isolated from melanoma patients, we endeavor to study the invasiveness and tumor microenvironment of these cells. We have shown&nbsp;in&hellip;<\/p>\n","category_list_v2":"Uncategorized","author_info_v2":{"name":"mmatlinski","url":"https:\/\/biotech.uwr.edu.pl\/en\/author\/mmatlinski\/"},"comments_num_v2":"0 comments","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Department of Cell Pathology - Wydzia\u0142 Biotechnologii<\/title>\n<meta name=\"description\" content=\"Wydzia\u0142 Biotechnologii\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biotech.uwr.edu.pl\/en\/department-of-cell-pathology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Department of Cell Pathology - Wydzia\u0142 Biotechnologii\" \/>\n<meta property=\"og:description\" content=\"Wydzia\u0142 Biotechnologii\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biotech.uwr.edu.pl\/en\/department-of-cell-pathology\/\" \/>\n<meta property=\"og:site_name\" content=\"Wydzia\u0142 Biotechnologii\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-27T13:32:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/09\/biotechnologia-fot.-Magdalena-Marcula-Biuro-ds.-Promocji-UWr-6.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1600\" \/>\n\t<meta property=\"og:image:height\" content=\"1067\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"18 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biotech.uwr.edu.pl\/en\/department-of-cell-pathology\/\",\"url\":\"https:\/\/biotech.uwr.edu.pl\/en\/department-of-cell-pathology\/\",\"name\":\"Department of Cell Pathology - 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