{"id":35893,"date":"2022-06-25T11:16:03","date_gmt":"2022-06-25T09:16:03","guid":{"rendered":"https:\/\/biotech.uwr.edu.pl\/zaklad-inzynierii-bialka\/"},"modified":"2023-03-22T09:29:21","modified_gmt":"2023-03-22T08:29:21","slug":"department-of-protein-engineering","status":"publish","type":"page","link":"https:\/\/biotech.uwr.edu.pl\/en\/department-of-protein-engineering\/","title":{"rendered":"Department of Protein Engineering"},"content":{"rendered":"\n<div class=\"wp-block-ugb-container ugb-container blok_nowa_podstrona ugb-8dda971 ugb-container--v2 ugb-container--design-plain ugb-main-block\"><div class=\"ugb-inner-block\"><div class=\"ugb-block-content\"><div class=\"ugb-container__wrapper ugb-8dda971-wrapper\"><div class=\"ugb-container__side\"><div class=\"ugb-container__content-wrapper ugb-8dda971-content-wrapper\">\n<div class=\"wp-block-columns bs-news-page is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column bs-kontakt-photo is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/06\/InzBialka3a.jpg\" alt=\"zip\" class=\"wp-image-35671\" width=\"288\" height=\"216\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column bs-contact-right-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-bonasoft-modular-breadcrumbs-block\"><div class=\"bs_add_breadcrumb_trail\"><\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-background has-black-background-color has-black-color is-style-wide bs-border-kontakt\"\/>\n\n\n\n<h1 class=\"bs-naglowek-podstrony wp-block-heading\"><strong>Department of Protein Engineering<\/strong><\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">DEPARTMENT HEAD<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/biotech.uwr.edu.pl\/lista-pracownikow\/?omegaId=UWR0afc3fe9b70842e3a4bc411c7871e4ca\">Prof. dr hab. Jacek Otlewski<\/a>&nbsp;<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">STAFF MEMBERS<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/biotech.uwr.edu.pl\/lista-pracownikow\/?omegaId=UWRcd0de5147d3d4a5ca6baf1a9489d7a68\">dr hab. in\u017c. Ma\u0142gorzata Zakrzewska, prof. Uwr<\/a><\/li><li><a href=\"https:\/\/biotech.uwr.edu.pl\/lista-pracownikow\/?omegaId=UWR1cf130a57db54253a18146bd7853f9b7\">dr Anna Szlachcic<\/a><\/li><li><a href=\"https:\/\/biotech.uwr.edu.pl\/lista-pracownikow\/?omegaId=UWRff32a295e5224b6f814e53eed86b29f4\">dr hab. \u0141ukasz Opali\u0144ski<\/a><\/li><li><a href=\"https:\/\/biotech.uwr.edu.pl\/lista-pracownikow\/?omegaId=UWR684a79e44a314c85bb1556edd9aa6bba\">dr Aleksandra Soko\u0142owska-W\u0119dzina<\/a><\/li><li><a href=\"https:\/\/biotech.uwr.edu.pl\/lista-pracownikow\/?omegaId=UWRd65fc27b85744d6199f93336682df936\" target=\"_blank\" rel=\"noreferrer noopener\">dr Dagmara Jakubowska<\/a><\/li><li><a href=\"https:\/\/biotech.uwr.edu.pl\/lista-pracownikow\/?omegaId=UWR017f1828cc85408ca1032d568039e0a3\" target=\"_blank\" rel=\"noreferrer noopener\">dr Katarzyna S\u0142u\u017calska<\/a><\/li><li><a href=\"https:\/\/biotech.uwr.edu.pl\/lista-pracownikow\/?omegaId=UWR22a1f8d1545f4abeb38737aea2fee467\">dr Monika Nahorska<\/a><\/li><li><a href=\"https:\/\/biotech.uwr.edu.pl\/lista-pracownikow\/?omegaId=UWR19a5dca7b6e24ca88fcb772187720714\" target=\"_blank\" rel=\"noreferrer noopener\">mgr Martyna Sochacka<\/a><\/li><\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-ugb-container ugb-container bs-news-page-under ugb-f8694ce ugb-container--v2 ugb-container--design-plain ugb-main-block\"><div class=\"ugb-inner-block\"><div class=\"ugb-block-content\"><div class=\"ugb-container__wrapper ugb-f8694ce-wrapper\"><div class=\"ugb-container__side\"><div class=\"ugb-container__content-wrapper ugb-f8694ce-content-wrapper\">\n<h3 class=\"wp-block-heading\">PhD Students<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>mgr Joanna Bober (Draus)<\/li><li>mgr in\u017c. Aleksandra Borek<\/li><li><a href=\"https:\/\/biotech.uwr.edu.pl\/lista-pracownikow\/?omegaId=UWR2c172cce2eb841d69b20048595472eda\">mgr Aleksandra Czyrek<\/a><\/li><li><a href=\"https:\/\/biotech.uwr.edu.pl\/lista-pracownikow\/?omegaId=UWR3abef647722644409e3e233ec7006978\">mgr Magdalena Lipok<\/a><\/li><\/ul>\n\n\n\n<div class=\"alignfull wp-block-ugb-container ugb-container podstrona-szachownica ugb-12c4a27 ugb-container--v2 ugb-container--design-plain ugb-main-block\"><style>@media screen and (min-width:768px){.ugb-12c4a27.ugb-container{margin-bottom:0px !important;padding-right:0px !important;padding-bottom:50px !important;padding-left:0px !important}}@media screen and (min-width:768px){.ugb-12c4a27 > .ugb-inner-block > .ugb-block-content > *{padding-top:0px !important;padding-bottom:0px !important;padding-right:0px !important;padding-left:0px !important}}<\/style><div class=\"ugb-inner-block\"><div class=\"ugb-block-content\"><div class=\"ugb-container__wrapper ugb-12c4a27-wrapper\"><div class=\"ugb-container__side\"><div class=\"ugb-container__content-wrapper ugb-12c4a27-content-wrapper\">\n<div class=\"wp-block-ugb-container ugb-container ugb-002ab8b ugb-container--v2 ugb-container--design-plain ugb-main-block\"><style>@media screen and (min-width:768px){.ugb-002ab8b.ugb-container{margin-bottom:0% !important;margin-right:6% !important;margin-left:6% !important}}@media screen and (min-width:768px){.ugb-002ab8b > .ugb-inner-block > .ugb-block-content > *{padding-top:0px !important;padding-bottom:0px !important;padding-right:0px !important;padding-left:0px !important}}<\/style><div class=\"ugb-inner-block\"><div class=\"ugb-block-content\"><div class=\"ugb-container__wrapper ugb-002ab8b-wrapper\"><div class=\"ugb-container__side\"><div class=\"ugb-container__content-wrapper ugb-002ab8b-content-wrapper\">\n<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile is-vertically-aligned-top tekst-zdjece-kwadrat tekst-zdjece-kwadrat-p\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" src=\"https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/06\/peb2.jpg\" alt=\"trdrf\" class=\"wp-image-35677 size-full\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<h2 class=\"wp-block-heading\">RESEARCH TOPICS<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Nanotechnology<\/li><li>Bioconjugates<\/li><li>Therapeutic Proteins<\/li><li>Protein Engineering<\/li><li>Phage Display<\/li><li>Aptamers<\/li><\/ul>\n<\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">PUBLIKACJE &#8211; WYBRANE PRACE <\/h3>\n\n\n\n<ol class=\"wp-block-list\"><li>Kim, M.H, Cierpicki, T., Derewenda, U., Krowarsch, D., Feng, Y., Devedjiev, Y., Dauter, Y., Walsh, C.A., Otlewski, J., Bushweller, J.H. &amp; Derewenda, Z.S. (2003) DCX-Domain Tandems of Doublecortin and Doublecortin-like Kinase: Implications for Microtubule Regulation. Nature Struct. Biol. 10, 324-333.<\/li><li>Zakrzewska, M., Krowarsch, D., Wiedlocha, A., Olsnes, S. Otlewski, J. (2005) Highly Stable Mutants of Human Fibroblast Growth Factor-1 Exhibit Prolonged Biological Action. J. Mol. Biol. 352, 860-875.<\/li><li>Zakrzewska M., Krowarsch D., Wi\u0119d\u0142ocha A., Olsnes S., Otlewski J. Structural requirements of FGF-1 for receptor binding and translocation into cells Biochemistry, 2006, 45, 15338-15348<\/li><li>Pasternak O., Bujasz G.D., Fujimoto Y., Hashimoto Y., Jele\u0144 F., Otlewski J., Sikorski M.M., Jask\u00f3lski M. Crystal structure of Vigna radiata cytokin-specific binding protein in complex with zeatin Plant Cell, 2006, 18, 2622-2634<\/li><li>Mateja A., Cierpicki T., Paduch M., Derewenda Z.S., Otlewski J. The dimerization mechanism of Lis1 and its implication for proteins containing the LisH motif J. Mol. Biol., 2006, 357, 621-631<\/li><li>Bia\u0142as A., Trembecka J., Krowarsch D., Otlewski J., Potempa J., Mucha A. Exploring the Sn Binding Pockets in Gingipains by Newly Developed Inhibitors: Structure-based Design, Chemistry and Activity J. Med. Chem., 2006, 46, 1744-1753<\/li><li>Oleksy A., Opali\u0144ski \u0141., Derewenda U., Derewenda Z.S., Otlewski J. The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF J. Biol. Chem., 2006, 281, 32891-32897<\/li><li>Ki\u0119dzierska A., \u015amietana K., Czepczy\u0144ska H., Otlewski J. Structural similarities and functional diversity of eukaryotic discoidin-like domains Biochim. Biophys. Acta, 2007, 1774, 1069-78<\/li><li>Paduch M., Biernat M., Stefanowicz P., Derewenda Z.S., Szewczuk Z., Otlewski J. Bivalent peptides as models for multimeric targets of PDZ domains ChemBioChem, 2007, 8, 443-452<\/li><li>Jele\u0144 F., Lachowicz P., Apostoluk W., Mateja A., Derewenda Z.S., Otlewski J. Dissecting the thermodynamics of GAP-RhoA interactions J Struct. Biol., 2009, 165, 10-8<\/li><\/ol>\n\n\n<div class=\"bs__links\">\r\n    <div class=\"bs__links__section\">\r\n        <ul class=\"bs__links__list\">\r\n                            <li class=\"bs__links__list__item\">\r\n                    <a href=\"http:\/\/www.protein.pl\/?name=publications\" class=\"bs__links__list__item__link\">\r\n                        List of all publications \r\n                        <div class=\"bs__links__list__item__link__before__icon\">\r\n                            <div class=\"bs__links__list__item__link__icon\">\r\n                                <svg width=\"40px\" height=\"40px\" viewBox=\"0 0 22 16\" version=\"1.1\">\r\n                                <g stroke=\"none\" strokeWidth=\"1\" fill=\"black\" fillRule=\"evenodd\">\r\n                                    <g>\r\n                                    <polygon points=\"13.4875 0 12 1.6215 18.7875 8 12 14.3795 13.4875 16 21.9995 8\" \/>\r\n                                    <\/g>\r\n                                <\/g>\r\n                                <\/svg>\r\n                            <\/div>\r\n                        <\/div>\r\n                    <\/a>\r\n                <li>\r\n                    <\/ul>\r\n    <\/div>\r\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Department of Protein Engineering DEPARTMENT HEAD Prof. dr hab. Jacek Otlewski&nbsp; STAFF MEMBERS dr hab. in\u017c. Ma\u0142gorzata Zakrzewska, prof. Uwr dr Anna Szlachcic dr hab. \u0141ukasz Opali\u0144ski dr Aleksandra Soko\u0142owska-W\u0119dzina dr Dagmara Jakubowska dr Katarzyna S\u0142u\u017calska dr Monika Nahorska mgr Martyna Sochacka PhD Students mgr Joanna Bober (Draus) mgr in\u017c. Aleksandra Borek mgr Aleksandra Czyrek [&hellip;]<\/p>\n","protected":false},"author":20,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[],"tags":[],"class_list":["post-35893","page","type-page","status-publish","hentry"],"featured_image_urls_v2":{"full":"","thumbnail":"","medium":"","medium_large":"","large":"","1536x1536":"","2048x2048":"","menu-24x24":"","menu-36x36":"","menu-48x48":""},"post_excerpt_stackable_v2":"<p>Department of Protein Engineering DEPARTMENT HEAD Prof. dr hab. Jacek Otlewski&nbsp; STAFF MEMBERS dr hab. in\u017c. Ma\u0142gorzata Zakrzewska, prof. Uwrdr Anna Szlachcicdr hab. \u0141ukasz Opali\u0144skidr Aleksandra Soko\u0142owska-W\u0119dzinadr Dagmara Jakubowskadr Katarzyna S\u0142u\u017calskadr Monika Nahorskamgr Martyna Sochacka PhD Students mgr Joanna Bober (Draus)mgr in\u017c. Aleksandra Borekmgr Aleksandra Czyrekmgr Magdalena Lipok RESEARCH TOPICS NanotechnologyBioconjugatesTherapeutic ProteinsProtein EngineeringPhage DisplayAptamers PUBLIKACJE &#8211; WYBRANE PRACE Kim, M.H, Cierpicki, T., Derewenda, U., Krowarsch, D., Feng, Y., Devedjiev, Y., Dauter, Y., Walsh, C.A., Otlewski, J., Bushweller, J.H. &amp; Derewenda, Z.S. (2003) DCX-Domain Tandems of Doublecortin and Doublecortin-like Kinase: Implications for Microtubule Regulation. Nature Struct. Biol. 10, 324-333.Zakrzewska, M., Krowarsch,&hellip;<\/p>\n","category_list_v2":"Uncategorized","author_info_v2":{"name":"mmatlinski","url":"https:\/\/biotech.uwr.edu.pl\/en\/author\/mmatlinski\/"},"comments_num_v2":"0 comments","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Department of Protein Engineering - Wydzia\u0142 Biotechnologii<\/title>\n<meta name=\"description\" content=\"Wydzia\u0142 Biotechnologii\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biotech.uwr.edu.pl\/zaklad-inzynierii-bialka\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Department of Protein Engineering - Wydzia\u0142 Biotechnologii\" \/>\n<meta property=\"og:description\" content=\"Wydzia\u0142 Biotechnologii\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biotech.uwr.edu.pl\/zaklad-inzynierii-bialka\/\" \/>\n<meta property=\"og:site_name\" content=\"Wydzia\u0142 Biotechnologii\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-22T08:29:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/biotech.uwr.edu.pl\/wp-content\/uploads\/sites\/261\/2022\/06\/InzBialka3a.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biotech.uwr.edu.pl\/zaklad-inzynierii-bialka\/\",\"url\":\"https:\/\/biotech.uwr.edu.pl\/zaklad-inzynierii-bialka\/\",\"name\":\"Department of Protein Engineering - 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