Interested

• porphyromonas gingivalis
• biochemistry molecular biology
• microbiology
• immunology
• dentistry
• general science technology
• chemical physics
• hmu system
• hus system
• periodontal diseases

Scientific discipline

• medical sciences
• biotechnology

Latest publications

• Hemophore-like proteins of the HmuY family in the oral and gut microbiome: unraveling the mystery of their evolution
• Production of interferon‐gamma, interleukin‐6, and interleukin‐1β by human peripheral blood mononuclear cells stimulated with novel lys‐gingipain synthetic peptides.
• Bacteroides fragilis expresses three proteins similar to Porphyromonas gingivalisHmuY: Hemophore‐like proteins differentially evolved to participate in heme acquisition in oral and gut microbiomes
• Glycation of host proteins increases pathogenic potential of Porphyromonas gingivalis.
• Unique properties of heme binding of the Porphyromonas gingivalis HmuY hemophore-like protein result from the evolutionary adaptation of the protein structure.
• SLC35A5 protein - a Golgi complex member with putative nucleotide sugar transport activity.
• Porphyromonas gingivalis HmuY and Streptococcus gordonii GAPDH—novel heme acquisition strategy in the oral microbiome.
• Porphyromonas gingivalis HmuY and Bacteroides vulgatus Bvu—A Novel Competitive Heme Acquisition Strategy
• Comparative analysis of Porphyromonas gingivalis A7436 and ATCC 33277 strains reveals differences in the expression of heme acquisition systems
• Interplay between Porphyromonas gingivalis hemophore-like protein HmuY and Kgp/RgpA gingipains plays a superior role in heme supply
• Prevotella intermedia produces two proteins homologous to Porphyromonas gingivalis HmuY but with different heme coordination mode.
• Novel synthetic peptide derived from Porphyromonas gingivalis Lys-gingipain detects IgG-mediated host response in periodontitis.
• Porphyromonas gingivalis PgFur is a member of a novel Fur subfamily with non-canonical function.
• Apoptosis transcriptional profile induced by Porphyromonas gingivalis HmuY.
• Porphyromonas endodontalis HmuY differentially participates in heme acquisition compared to the Porphyromonas gingivalis and Tannerella forsythia hemophore-like proteins
• Biosynthesis of GlcNAc-rich N- and O-glycans in the Golgi apparatus does not require the nucleotide sugar transporter SLC35A3
• Hemophore-like proteins produced by periodontopathogens are recognized by the host immune system and react differentially with IgG antibodies
• In silico analysis as a strategy to identify candidate epitopes with human IgG reactivity to study Porphyromonas gingivalis virulence factors.
• PgFur participates differentially in expression of virulence factors in more virulent A7436 and less virulent ATCC 33277 Porphyromonas gingivalis strains.
• Lysine at position 329 within a C-terminal dilysine motif is crucial for the ER localization of human SLC35B4.