Interested

• biochemistry molecular biology
• signaling
• fgfr
• medicinal biomolecular chemistry
• fgf
• fgfs
• galectins
• multivalency
• n glycosylation
• fhfs

Scientific discipline

• biotechnology
• biomedical engineering

Latest publications

• FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner.
• Nuclear localization sequence of FGF1 is not required for its intracellular anti-apoptotic activity in differentiated cells.
• Cross-talk between fibroblast growth factor receptors and other cell surface proteins.
• Low stability of integrin-binding deficient mutant of FGF1 restricts its biological activity.
• Fructose 1,6-Bisphosphatase 2 Plays a Crucial Role in the Induction and Maintenance of Long-Term Potentiation
• Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling
• FGF homologous factors are secreted from cells to induce FGFR‐mediated anti‐apoptotic response
• Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling
• Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1.
• FGF1 protects MCF-7 cells against taltobulin through both the MEKs/ERKs and PI3K/AKT signaling pathway
• Identification of a peptide antagonist of the FGF1–FGFR1 signaling axis by phage display selection.
• Site-specific conjugation of fibroblast growth factor 2 (FGF2) based on incorporation of alkyne-reactive unnatural amino acid.