Interested

• biochemistry molecular biology
• fgfr1
• receptor
• growth factor
• cancer
• signaling
• fgf
• chemical physics
• galectins
• fgfr

Scientific discipline

• medical sciences
• biotechnology

Latest publications

• Multivalent protein-drug conjugates – an emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells
• FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner.
• Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins.
• Cross-talk between fibroblast growth factor receptors and other cell surface proteins.
• Stable fibroblast growth factor 2 dimers with high pro-survival and mitogenic potential.
• Intrinsically fluorescent oligomeric cytotoxic conjugates toxic for FGFR1-overproducing cancers.
• Low stability of integrin-binding deficient mutant of FGF1 restricts its biological activity.
• IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A
• Crosstalk between p38 and Erk 1/2 in downregulation of FGF1-induced signaling.
• FGF2-derived peptibodyF2-MMAE conjugate for targeted delivery of cytotoxic drugs into cancer cells overexpressing FGFR1.
• FGF/FGFR-dependent molecular mechanisms underlying anti-cancer drug resistance.
• Novel method for preparation of site-specific, stoichiometric-controlled dual warhead conjugate of FGF2 via dimerization employing sortase a-mediated ligation.
• FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization.
• Targeting cellular trafficking of fibroblast growth factor receptors as a strategy for selective cancer treatment.
• N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope
• Galectins as modulators of receptor tyrosine kinases signaling in health and disease
• Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling
• The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases
• FGF homologous factors are secreted from cells to induce FGFR‐mediated anti‐apoptotic response
• Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs