Interested

• streptomyces
• sporulation
• microbiology
• biotechnology
• chromosomes
• dna supercoiling
• transcriptional regulation
• nucleoid associated proteins naps
• topoisomerases
• stress response

Scientific discipline

• biotechnology
• medical sciences

Latest publications

• Compaction and control - the role of chromosome-organizing proteins in Streptomyces.
• Enhanced binding of an HU homologue under increased DNA supercoiling preserves chromosome organisation and sustains Streptomyces hyphal growth
• Spatial rearrangement of the Streptomyces venezuelae linear chromosome during sporogenic development
• Global Chromosome Topology and the Two-Component Systems in Concerted Manner Regulate Transcription in Streptomyces
• Combining transposon mutagenesis and reporter genes to identify novel regulators of the topA promoter in Streptomyces.
• Chromosome segregation proteins as coordinators of cell cycle in response to environmental conditions.
• Competition between DivIVA and the nucleoid for ParA binding promotes segrosome separation and modulates mycobacterial cell elongation.
• Genus-specific interactions of bacterial chromosome segregation machinery are critical for their function
• Transcriptional response of Streptomyces coelicolor to rapid chromosome relaxation or long-term supercoiling imbalance.
• The interplay between the polar growth determinant DivIVA, the segregation protein ParA, and their novel interaction partner PapM controls the Mycobacterium smegmatis cell cycle by modulation of DivIVA subcellular distribution
• A highly processive actinobacterial topoisomerase I – thoughts on Streptomyces’ demand for an enzyme with a unique C-terminal domain.
• Streptomycete origin of chromosomal replication with two putative unwinding elements.
• Multifork chromosome replication in slow-growing bacteria.
• The studies of ParA and ParB dynamics reveal asymmetry of chromosome segregation in mycobacteria.
• C-terminal lysine repeats in Streptomyces topoisomerase I stabilize the enzyme-DNA complex and confer high enzyme processivity.
• HupB is a bacterial nucleoid-associated protein with an indispensable eukaryotic-like tail.
• Amsacrine derivatives selectively inhibit Mycobacterial topoisomerase I (TopA), impair M. smegmatis growth and disturb chromosome replication.
• The origin of chromosomal replication is asymmetrically positioned on the mycobacterial nucleoid, and the timing of its firing depends on HupB.