Interested

• streptomyces
• sporulation
• chromosomes
• dna supercoiling
• microbiology
• biotechnology
• topoisomerases
• bacterial genetics
• two component system
• bacterial development

Scientific discipline

• biotechnology
• medical sciences

Latest publications

• Compaction and control - the role of chromosome-organizing proteins in Streptomyces.
• Enhanced binding of an HU homologue under increased DNA supercoiling preserves chromosome organisation and sustains Streptomyces hyphal growth
• Spatial rearrangement of the Streptomyces venezuelae linear chromosome during sporogenic development
• Global Chromosome Topology and the Two-Component Systems in Concerted Manner Regulate Transcription in Streptomyces
• Combining transposon mutagenesis and reporter genes to identify novel regulators of the topA promoter in Streptomyces.
• Transcriptional response of Streptomyces coelicolor to rapid chromosome relaxation or long-term supercoiling imbalance.
• A highly processive actinobacterial topoisomerase I – thoughts on Streptomyces’ demand for an enzyme with a unique C-terminal domain.
• C-terminal lysine repeats in Streptomyces topoisomerase I stabilize the enzyme-DNA complex and confer high enzyme processivity.
• Amsacrine derivatives selectively inhibit Mycobacterial topoisomerase I (TopA), impair M. smegmatis growth and disturb chromosome replication.