Interested

• biochemistry molecular biology
• growth factor
• signaling
• galectins
• cancer
• receptor
• fgfr1
• glycosylation
• fgf
• galectin 8

Scientific discipline

• medical sciences
• biotechnology

Latest publications

• Multivalent protein-drug conjugates – an emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells
• Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins.
• Cross-talk between fibroblast growth factor receptors and other cell surface proteins.
• Intrinsically fluorescent oligomeric cytotoxic conjugates toxic for FGFR1-overproducing cancers.
• FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization.
• Targeting cellular trafficking of fibroblast growth factor receptors as a strategy for selective cancer treatment.
• N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope
• Galectins as modulators of receptor tyrosine kinases signaling in health and disease
• Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling
• The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases
• Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs
• The intracellular interplay between galectin-1 and FGF12 in the assembly of ribosome biogenesis complex
• Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling
• The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis
• The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells.
• Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1.
• Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors.
• FGF1 fusions with the Fc fragment of IgG1 for the assembly of GFPpolygons-mediated multivalent complexes recognizing FGFRs.
• Preparation of site-specific cytotoxic protein conjugates via maleimide-thiol chemistry and sortase A-mediated ligation.