
natalia.porebska@uwr.edu.pl
tel. +48 71 375 28 88
Interested
- biochemistry molecular biology
- polymers
- signaling
- galectin 8
- biotechnology
- crd
- immunology
- multivalency
- cell migration
- cell proliferation
Scientific discipline
- medical sciences
- biotechnology
Latest publications
- Multivalent protein-drug conjugates – an emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells
- Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins.
- Cross-talk between fibroblast growth factor receptors and other cell surface proteins.
- Intrinsically fluorescent oligomeric cytotoxic conjugates toxic for FGFR1-overproducing cancers.
- FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization.
- Targeting cellular trafficking of fibroblast growth factor receptors as a strategy for selective cancer treatment.
- N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope
- Galectins as modulators of receptor tyrosine kinases signaling in health and disease
- Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling
- The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases
- Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs
- The intracellular interplay between galectin-1 and FGF12 in the assembly of ribosome biogenesis complex
- Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling
- The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis
- The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells.
- Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1.
- Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors.
- FGF1 fusions with the Fc fragment of IgG1 for the assembly of GFPpolygons-mediated multivalent complexes recognizing FGFRs.
- Preparation of site-specific cytotoxic protein conjugates via maleimide-thiol chemistry and sortase A-mediated ligation.