Interested

• organic chemistry
• materials
• chemical engineering
• delivery system
• cancer
• stability
• candida
• microbiology
• chemical physics
• pancreatic cancer

Scientific discipline

• biomedical engineering
• medical sciences

Latest publications

• Coordination of fungal biofilm development by extracellular vesicle cargo.
• A common vesicle proteome drives fungal biofilm development
• Azacarbazole n-3 and n-6 polyunsaturated fatty acids ethyl esters nanoemulsion with enhanced efficacy against Plasmodium falciparum
• Impact of N-alkylamino substituents on serotonin receptor (5-HTR) affinity and phosphodiesterase 10A (PDE10A) inhibition of isoindole-1,3-dione derivatives.
• A triple co-delivery liposomal carrier that enhances apoptosis via an intrinsic pathway in melanoma cells.
• The conjugates of indolo[2,3-b]quinoline as anti-pancreatic cancer agents: design, synthesis, molecular docking and biological evaluations
• Design, synthesis, and in vitro antiproliferative activity of hydantoin and purine derivatives with the 4-acetylphenylpiperazinylalkyl moiety.
• Drug discovery and development targeting dementia
• The development of the innovative synthesis methodology of albumin nanoparticles supported by their physicochemical, cytotoxic and hemolytic evaluation.
• Synthesis and physicochemical evaluation of bees’ chitosan-based hydrogels modified with yellow tea extract.
• Perspectives for new and more efficient multifunctional ligands for Alzheimer′s disease therapy.
• Liposomal formulation of a new antifungal hybrid compound provides protection against Candida auris in the ex vivo skin colonization model
• A label-free cellular proteomics approach to decipher the antifungal action of DiMIQ, a potent indolo[2,3-b]quinoline agent, against Candida albicans biofilms.
• Physicochemical investigations of chitosan-based hydrogels containing Aloe vera designed for biomedical use.
• Evaluation of the in vitro cytotoxic activity of caffeic acid derivatives and liposomal formulation against pancreatic cancer cell lines.
• The antidepressant-like activity, effects on recognition memory deficits, bioavailability, and safety after chronic administration of new dual-acting small compounds targeting neuropsychiatric symptoms in dementia
• Solvothermally-derived nanoglass as a highly bioactive material.
• Design, synthesis, and behavioral evaluation of dual-acting compounds as phosphodiesterase type 10A (PDE10A) inhibitors and serotonin ligands targeting neuropsychiatric symptoms in dementia.
• Synthesis, molecular docking and antiplasmodial activities of new tetrahydro-β-carbolines.
• Synthesis, computational simulations and biological evaluation of new dual 5HT_1A/5HT₇ receptor ligands based on purine-2,6-dione scaffold