Interested

• organic chemistry
• chemical physics
• immunology
• endocrinology metabolism
• nutrition dietetics

Scientific discipline

• medical sciences
• biotechnology

Latest publications

• Vitamin D analogs regulate the vitamin D system and cell viability in ovarian cancer cells.
• Vitamin D derivatives in acute myeloid leukemia: the matter of selecting the right targets
• Regulation of FOXP3 expression in myeloid cells in response to all-trans-retinoic acid, interleukin 2 and transforming growth factor β.
• Immuno-stimulating activity of 1,25-dihydroxyvitamin D in blood cells from five healthy people and in blasts from five patients with leukemias and pre-leukemic states
• Investigating the Role of Methylation in Silencing of VDR Gene Expression in Normal Cells during Hematopoiesis and in Their Leukemic Counterparts
• Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-nor Analogs of Vitamin D
• Design, synthesis and biological evaluation of novel 2-alkylidene 19-norcalcitriol analogs.
• Lithocholic acid-based design of noncalcemic vitamin D receptor agonists.
• Synthesis of Gemini analogs of 19-norcalcitriol and their platinum(II) complexes.
• Synthesis of 19-norcalcitriol analogs with pegylated alkylidene chains at C-2.
• Overexpressed fibroblast growth factor receptors increase 1,25-dihydroxyvitamin D-dependent differentiation of acute myeloid leukemia cells
• Vitamin D and immune system
• Regulation of expression of CEBP genes by variably expressed vitamin D receptor and retinoic acid receptor α in human acute myeloid leukemia cell lines.
• Seco-B-ring steroidal dienynes with aromatic D ring: design, synthesis and biological evaluation.
• Diverse regulation of vitamin D receptor gene expression by 1,25-dihydroxyvitamin D and ATRA in murine and human blood cells at early stages of their differentiation.
• Synthesis of 19-norcalcitriol analogs with elongated side chain.
• Antagonizing retinoic acid receptors increases myeloid cell production by cultured human hematopoietic stem cells.
• The vitamin D system in humans and mice: similar but not the same.
• Antiproliferative and immunoregulatory actions of vitamin D derivatives on hematological malignancies
• Vitamin D and Leukaemia.