Interested

• biochemistry molecular biology
• organic chemistry
• general science technology
• chemical physics
• immunology
• oncology carcinogenesis

Scientific discipline

• medical sciences
• biomedical engineering

Latest publications

• FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization.
• The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells.
• Preparation of site-specific cytotoxic protein conjugates via maleimide-thiol chemistry and sortase A-mediated ligation.
• High-yield site-specific conjugation of fibroblast growth factor 1 with monomethylauristatin E via cysteine flanked by basic residues.
• Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity.
• Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers.
• The autoinhibitory function of D1 domain of FGFR1 goes beyond the inhibition of ligand binding.
• High-affinity internalizing human scFv-Fc antibody for targeting FGFR1-Overexpressing lung cancer.
• Design and in vitro evaluation of a cytotoxic conjugate based on the anti-HER2 affibody fused to the Fc fragment of IgG1.
• Cytotoxic conjugates of fibroblast growth factor 2 (FGF2) with monomethyl auristatin E for effective killing of cells expressing FGF receptors.