Interested

• biochemistry molecular biology
• general chemistry
• analytical chemistry
• metals
• organic chemistry
• metal binding
• metallothionein
• biophysics
• stability
• spectroscopy

Scientific discipline

• biomedical engineering
• medical sciences

Latest publications

• The glutathione/metallothionein system challenges the design of efficient O2‐activating copper complexes.
• Structures of silver fingers and a pathway to their genotoxicity.
• An integrated mass spectrometry and molecular dynamics simulations approach reveals the spatial organization impact of metal-binding sites on the stability of metal-depleted metallothionein-2 species.
• Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function.
• Galvanization of protein–protein interactions in a dynamic zinc interactome.
• The bioinorganic chemistry of mammalian metallothioneins.
• Ion mobility mass spectrometry and molecular dynamics simulations unravel the conformational stability of zinc metallothionein-2 species
• HP1021 is a redox switch protein identified in Helicobacter pylori.
• Structural Characterization of Cu(I)/Zn(II)-metallothionein-3 by Ion Mobility Mass Spectrometry and Top-Down Mass Spectrometry
• An extremely stable interprotein tetrahedral Hg(Cys)₄ core forms in the zinc hook domain of Rad50 protein at physiological pH
• Metal exchange in the interprotein ZnII‐binding site of the Rad50 hook domain: structural insights into CdII‐induced DNA‐repair inhibition.
• Nesfatin-3 possesses divalent metal ion binding properties, which remain hidden in the nucleobindin-2 precursor protein
• Does one plus one always equal two? Structural differences between nesfatin-1, -2, and nesfatin-1/2
• A guide to good practice in chemometric methods for vibrational spectroscopy, electrochemistry, and hyphenated mass spectrometry.
• Calcium-assisted sortase A cleavage of SUMOylated metallothionein constructs leads to high-yield production of human MT3
• Metal- and affinity-specific dual labeling of cysteine-rich proteins for identification of metal-binding sites.
• Non-conserved amino acid residues modulate the thermodynamics of Zn(II) binding to classical ββα zinc finger domains
• Direct interaction of ATP7B and LC3B proteins suggests a cooperative role of copper transportation and autophagy.
• An overlooked hepcidin–cadmium connection
• Relations between structure and Zn(II) binding affinity shed light on the mechanisms of Rad50 hook domain functioning and its phosphorylation