Interested

• biochemistry molecular biology
• analytical chemistry
• general chemistry
• metallothionein
• organic chemistry
• metal binding
• chemical physics
• environmental sciences
• native mass spectrometry
• proteoform

Scientific discipline

• biomedical engineering

Latest publications

• The glutathione/metallothionein system challenges the design of efficient O2‐activating copper complexes.
• An integrated mass spectrometry and molecular dynamics simulations approach reveals the spatial organization impact of metal-binding sites on the stability of metal-depleted metallothionein-2 species.
• Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function.
• Ion mobility mass spectrometry and molecular dynamics simulations unravel the conformational stability of zinc metallothionein-2 species
• Structural Characterization of Cu(I)/Zn(II)-metallothionein-3 by Ion Mobility Mass Spectrometry and Top-Down Mass Spectrometry
• A guide to good practice in chemometric methods for vibrational spectroscopy, electrochemistry, and hyphenated mass spectrometry.
• Current landscape of non-small cell lung cancer: epidemiology, histological classification, targeted therapies, and immunotherapy.
• Metal- and affinity-specific dual labeling of cysteine-rich proteins for identification of metal-binding sites.
• Non-conserved amino acid residues modulate the thermodynamics of Zn(II) binding to classical ββα zinc finger domains
• An overlooked hepcidin–cadmium connection
• Prolonged cold-preservation of domestic cat ovarian tissue is improved by extracellular solution but impaired by the fragmentation of ovary
• Reactivity of Cu(ii)–, Zn(ii)– and Fe(ii)–thiosemicarbazone complexes with glutathione and metallothionein: from stability to dissociation to transmetallation.
• Chemometrics-assisted optimization of liquid chromatography-quadrupole-time-of-flight mass spectrometry analysis for targeted metabolomics.
• A chemometric-assisted voltammetric analysis of free and Zn(II)-loaded metallothionein-3 states.
• R-MetaboList 2: a flexible tool for metabolite annotation from high-resolution data-independent acquisition mass spectrometry analysis.
• Mass spectrometry-based structural analysis of cysteine-rich metal-binding sites in proteins with MetaOdysseus R software.
• The connection of α- and β-domains in mammalian metallothionein-2 differentiates Zn(II) binding affinities, affects folding, and determines zinc buffering properties
• Multiobjective optimization of liquid chromatography–triple-quadrupole mass spectrometry analysis of underivatized human urinary amino acids through chemometrics.
• Crosstalk of the structural and zinc buffering properties of mammalian metallothionein-2.
• Raman spectroscopy coupled to chemometrics to discriminate provenance and geological age of amber.