Department of Protein Engineering
DEPARTMENT HEAD
STAFF MEMBERS
PhD Students
- mgr Joanna Bober (Draus)
- mgr inż. Aleksandra Borek
- mgr Aleksandra Czyrek
- mgr Magdalena Lipok
RESEARCH TOPICS
- Nanotechnology
- Bioconjugates
- Therapeutic Proteins
- Protein Engineering
- Phage Display
- Aptamers
PUBLIKACJE – WYBRANE PRACE
- Kim, M.H, Cierpicki, T., Derewenda, U., Krowarsch, D., Feng, Y., Devedjiev, Y., Dauter, Y., Walsh, C.A., Otlewski, J., Bushweller, J.H. & Derewenda, Z.S. (2003) DCX-Domain Tandems of Doublecortin and Doublecortin-like Kinase: Implications for Microtubule Regulation. Nature Struct. Biol. 10, 324-333.
- Zakrzewska, M., Krowarsch, D., Wiedlocha, A., Olsnes, S. Otlewski, J. (2005) Highly Stable Mutants of Human Fibroblast Growth Factor-1 Exhibit Prolonged Biological Action. J. Mol. Biol. 352, 860-875.
- Zakrzewska M., Krowarsch D., Więdłocha A., Olsnes S., Otlewski J. Structural requirements of FGF-1 for receptor binding and translocation into cells Biochemistry, 2006, 45, 15338-15348
- Pasternak O., Bujasz G.D., Fujimoto Y., Hashimoto Y., Jeleń F., Otlewski J., Sikorski M.M., Jaskólski M. Crystal structure of Vigna radiata cytokin-specific binding protein in complex with zeatin Plant Cell, 2006, 18, 2622-2634
- Mateja A., Cierpicki T., Paduch M., Derewenda Z.S., Otlewski J. The dimerization mechanism of Lis1 and its implication for proteins containing the LisH motif J. Mol. Biol., 2006, 357, 621-631
- Białas A., Trembecka J., Krowarsch D., Otlewski J., Potempa J., Mucha A. Exploring the Sn Binding Pockets in Gingipains by Newly Developed Inhibitors: Structure-based Design, Chemistry and Activity J. Med. Chem., 2006, 46, 1744-1753
- Oleksy A., Opaliński Ł., Derewenda U., Derewenda Z.S., Otlewski J. The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF J. Biol. Chem., 2006, 281, 32891-32897
- Kiędzierska A., Śmietana K., Czepczyńska H., Otlewski J. Structural similarities and functional diversity of eukaryotic discoidin-like domains Biochim. Biophys. Acta, 2007, 1774, 1069-78
- Paduch M., Biernat M., Stefanowicz P., Derewenda Z.S., Szewczuk Z., Otlewski J. Bivalent peptides as models for multimeric targets of PDZ domains ChemBioChem, 2007, 8, 443-452
- Jeleń F., Lachowicz P., Apostoluk W., Mateja A., Derewenda Z.S., Otlewski J. Dissecting the thermodynamics of GAP-RhoA interactions J Struct. Biol., 2009, 165, 10-8
